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Advances in PET imaging of protein aggregates associated with neurodegenerative disease

Neurodegenerative diseases such as Alzheimer disease, Parkinson disease, frontotemporal lobar degeneration and multiple system atrophy are characterized pathologically by deposition of specific proteins in the brain. This article reviews the latest advances in the development of PET radiotracers for neurodegenerative proteinopathies and highlights the diagnostic and therapeutic applications of this technology.

Makoto Higuchi
Kenji Tagai
Hironobu Endo
Reviews11 Aug 2025
Nature Reviews Neurology

Volume: 21, P: 506-522
Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, ¹⁸F-SPAL-T-06 and ¹⁸F-C05-05

Ryoji Goto
Kiwamu Matsuoka
Hironobu Endo
ResearchOpen Access13 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder

Yasunori Sano
Yasuharu Yamamoto
Keisuke Takahata
ResearchOpen Access02 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-7
Preparation and Characterization of Polyoxetane Resins Having a Primary Amino Group at the Side Chain-End through Moderately Long Spacer Arms

Masatoshi Motoi
Satoshi Sekizawa
Shigeyoshi Kanoh
Research01 Dec 1993
Polymer Journal

Volume: 25, P: 1283-1294
Association between mammillary body atrophy and memory impairment in retired athletes with a history of repetitive mild traumatic brain injury

Mari Miyata
Keisuke Takahata
Makoto Higuchi
ResearchOpen Access26 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
Comparative transcriptome analysis implied a ZEP paralog was a key gene involved in carotenoid accumulation in yellow-fleshed sweetpotato

Keisuke Suematsu
Masaru Tanaka
Yumi Kai
ResearchOpen Access26 Nov 2020
Scientific Reports

Volume: 10, P: 1-11
Author Correction: Heterogeneous nitrogen fixation rates confer energetic advantage and expanded ecological niche of unicellular diazotroph populations

Takako Masuda
Keisuke Inomura
Ken Furuya
Amendments and CorrectionsOpen Access07 Jun 2023
Communications Biology

Volume: 6, P: 1
Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism

Masaki Oya
Kiwamu Matsuoka
Makoto Higuchi
ResearchOpen Access19 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
Amyloid-β prediction machine learning model using source-based morphometry across neurocognitive disorders

Yuki Momota
Shogyoku Bun
Masaru Mimura
ResearchOpen Access01 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
Neuromolecular basis of faded perception associated with unreality experience

Keita Yokokawa
Takehito Ito
Makiko Yamada
ResearchOpen Access23 May 2018
Scientific Reports

Volume: 8, P: 1-9
Heterogeneous nitrogen fixation rates confer energetic advantage and expanded ecological niche of unicellular diazotroph populations

Takako Masuda et al. show that individual cells in clonal populations of Crocosphaera watsonii and Cyanothece sp exhibit varied nitrogen fixation rates. This heterogeneity within the population decreases the energetic cost of respiration and expands the viable habitats for these unicellular diazotrophs.

Takako Masuda
Keisuke Inomura
Ken Furuya
ResearchOpen Access14 Apr 2020
Communications Biology

Volume: 3, P: 1-12
Excess tau PET ligand retention in elderly patients with major depressive disorder

Sho Moriguchi
Keisuke Takahata
Makoto Higuchi
Research01 Jul 2020
Molecular Psychiatry

Volume: 26, P: 5856-5863
Altered awareness of action in Parkinson’s disease: evaluations by explicit and implicit measures

Naho Saito
Keisuke Takahata
Hidehiko Takahashi
ResearchOpen Access14 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Adjunctive antimicrobial chemotherapy based on hydrogen peroxide photolysis for non-surgical treatment of moderate to severe periodontitis: a randomized controlled trial

Taro Kanno
Keisuke Nakamura
Keiichi Sasaki
ResearchOpen Access25 Sept 2017
Scientific Reports

Volume: 7, P: 1-10

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Advances in PET imaging of protein aggregates associated with neurodegenerative disease

Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, ¹⁸F-SPAL-T-06 and ¹⁸F-C05-05

Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder

Preparation and Characterization of Polyoxetane Resins Having a Primary Amino Group at the Side Chain-End through Moderately Long Spacer Arms

Association between mammillary body atrophy and memory impairment in retired athletes with a history of repetitive mild traumatic brain injury

Comparative transcriptome analysis implied a ZEP paralog was a key gene involved in carotenoid accumulation in yellow-fleshed sweetpotato

Author Correction: Heterogeneous nitrogen fixation rates confer energetic advantage and expanded ecological niche of unicellular diazotroph populations

Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism

Amyloid-β prediction machine learning model using source-based morphometry across neurocognitive disorders

Neuromolecular basis of faded perception associated with unreality experience

Heterogeneous nitrogen fixation rates confer energetic advantage and expanded ecological niche of unicellular diazotroph populations

Excess tau PET ligand retention in elderly patients with major depressive disorder

Altered awareness of action in Parkinson’s disease: evaluations by explicit and implicit measures

Adjunctive antimicrobial chemotherapy based on hydrogen peroxide photolysis for non-surgical treatment of moderate to severe periodontitis: a randomized controlled trial

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