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Showing 1–14 of 14 results
Advanced filters: Author: Keith D. Lindor Clear advanced filters

  • Primary sclerosing cholangitis (PSC) is understood to be associated with an increased risk of malignancy in the bile ducts, gallbladder and colon. The risk of hepatocellular carcinoma in the setting of PSC, however, is not well defined. Zenouzi et al. provide an analysis of their experience in a recent article

    • Andrea A. Gossard
    • Keith D. Lindor
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 11, P: 276-277

  • Primary sclerosing cholangitis (PSC) is a progressive inflammatory and fibrosing condition, which can lead to chronic cholestasis and biliary cirrhosis. The pathogenesis of PSC is not clearly understood; therapies that impact disease progression are currently limited—liver transplantation is the only curative treatment modality. This Review provides an update on the current understanding and management of this condition and its associated complications.

    • Flavia Mendes
    • Keith D. Lindor
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 7, P: 611-619

  • Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide and genetic susceptibility to the disease is poorly understood. Here, the authors combine data from Japanese, African American and European samples and identify a common variant in VTI1Athat increases CRC risk across all populations.

    • Hansong Wang
    • Terrilea Burnett
    • Loïc Le Marchand
    Research
    Nature Communications
    Volume: 5, P: 1-7

  • Oestrogen negative breast cancer is associated with a poor prognosis. In this study, the authors perform a meta-analysis of 11 breast cancer genome-wide association studies and identify four new loci associated with oestrogen negative breast cancer risk. These findings may aid in stratifying patients in the clinic.

    • Fergus J. Couch
    • Karoline B. Kuchenbaecker
    • Antonis C. Antoniou
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.

    • Jeroen R. Huyghe
    • Stephanie A. Bien
    • Ulrike Peters
    Research
    Nature Genetics
    Volume: 51, P: 76-87

  • Alison Dunning, Stacey Edwards and colleagues analyze 3,872 common variants across the ESR1 locus in 118,816 women. They find five independent variants within regulatory regions that associate with different breast cancer–related phenotypes and regulate the expression of ESR1, RMND1 and CCDC170.

    • Alison M Dunning
    • Kyriaki Michailidou
    • Stacey L Edwards
    Research
    Nature Genetics
    Volume: 48, P: 374-386

  • Previous studies have shown that both rare pathogenic mutations and common genetic variants contribute to the familial risk of developing colorectal cancer. Here, the authors carry out a two-stage genome-wide association study and identify six new loci associated with colorectal cancer.

    • Fredrick R. Schumacher
    • Stephanie L. Schmit
    • Ulrike Peters
    Research
    Nature Communications
    Volume: 6, P: 1-7

  • Fatigue is a common symptom of primary biliary cirrhosis (PBC) yet little is understood about the pathogenesis of this condition and there is no specific treatment. In this Review article, Abbas and colleagues discuss the natural history and measurement of fatigue in patients with PBC. The central and the peripheral mechanisms that have been suggested for the pathogenesis of fatigue in PBC are also described and treatment options are outlined.

    • Ghulam Abbas
    • Roberta A. Jorgensen
    • Keith D. Lindor
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 7, P: 313-319

  • Primary biliary cirrhosis (PBC) leads to progressive cholestasis, biliary fibrosis and cirrhosis and characteristic symptoms with a marked effect on quality of life. Evolution in our understanding of disease mechanisms in PBC is rapidly leading to the advent of new and re-purposed therapeutic agents targeting key processes. This Review provides a current perspective on potential approaches to PBC treatment, and highlights the challenges faced in evaluating and implementing those treatments.

    • Jessica K. Dyson
    • Gideon M. Hirschfield
    • David E. J. Jones
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 12, P: 147-158

  • Air surveillance offers a potential means of monitoring airborne pathogens without the need for individual sampling. Here, the authors perform continuous air sampling in 15 community settings in the US for 29 weeks and demonstrate its feasibility for routine detection of SARS-CoV-2 and other respiratory pathogens.

    • Mitchell D. Ramuta
    • Christina M. Newman
    • Shelby L. O’Connor
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14