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Showing 1–2 of 2 results
Advanced filters: Author: Keith P. Eidell Clear advanced filters

  • CAR-T therapy is a promising treatment modality for B-cell malignancies, yet many patients relapse. Using an in vivo genomewide screen in a model of B cell leukemia, we identify an unexpected mechanism of CAR-T resistance in which interferon gamma from the in vivo tumor microenvironment induces an adaptive T-cell resistance program in tumor cells.

    • Azucena Ramos
    • Catherine E. Koch
    • Michael T. Hemann
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • In immunocompetent hosts, the ablation of FAS and CD3 in allogeneic chimeric antigen receptor T cells confers them with partial protection from rejection by T cells and natural killer cells.

    • Keith P. Eidell
    • Michael T. Hemann
    News & Views
    Nature Biomedical Engineering
    Volume: 8, P: 1518-1520