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Dietary zinc deficiency promotes Acinetobacter baumannii lung infection via IL-13 in mice

Increased IL-13 drives increased bacterial dissemination and mortality following Acinetobacter baumannii lung infection of zinc-deficient mice and can be countered by anti-IL-13 antibody therapy.

Lauren D. Palmer
Kacie A. Traina
Eric P. Skaar
Research15 Nov 2024
Nature Microbiology

Volume: 9, P: 3196-3209
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

Insights into the function of Hax1 are provided by a study showing that Hax1 facilitates the processing of the mitochondrial protease HtrA2 by the mitochondrial rhomboid protease Parl. It is the protease activity of HtrA2 that is essential to suppress apoptosis in both lymphocytes and striatal neurons.

Jyh-Rong Chao
Evan Parganas
James N. Ihle
Research20 Feb 2008
Nature

Volume: 452, P: 98-102
Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy

Perinatal infection with Group B Streptococcus (GBS) is associated with preterm birth, neonatal sepsis, and stillbirth. Here, Korir et al. show that gene cadD, encoding a putative metal efflux transporter, is important for metal detoxification, immune evasion and bacterial proliferation in the pregnant host.

Michelle L. Korir
Ryan S. Doster
Jennifer A. Gaddy
ResearchOpen Access14 Sept 2022
Nature Communications

Volume: 13, P: 1-17
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of transcriptional repressor HIC1.

Xueping Liu
Dorte Helenius
Bjarke Feenstra
ResearchOpen Access02 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Natasha L Harvey
R Sathish Srinivasan
Guillermo Oliver
Research18 Sept 2005
Nature Genetics

Volume: 37, P: 1072-1081
Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

Jeff Holst
Haopeng Wang
Dario A A Vignali
Research11 May 2008
Nature Immunology

Volume: 9, P: 658-666
The receptor S1P₁ overrides regulatory T cell–mediated immune suppression through Akt-mTOR

Regulatory T cells (T_reg cells) are necessary for maintaining peripheral tolerance. Chi and colleagues show that the receptor S1P₁ negatively regulates thymic T_reg cell production and blocks T_reg cell activity via an Akt-mTor pathway.

Guangwei Liu
Samir Burns
Hongbo Chi
Research31 May 2009
Nature Immunology

Volume: 10, P: 769-777
The inhibitory cytokine IL-35 contributes to regulatory T-cell function

Regulatory T cells suppress immune function by direct cell to cell contact and secretion of the cytokines IL-10 and TGF-β. In this paper, a novel member of the IL-12 cytokine family that contributes to Treg function is identified.

Lauren W. Collison
Creg J. Workman
Dario A. A. Vignali
Research22 Nov 2007
Nature

Volume: 450, P: 566-569
No observed association for mitochondrial SNPs with preterm delivery and related outcomes

Brandon W. Alleman
Solveig Myking
Jeffrey C. Murray
Research17 Aug 2012
Pediatric Research

Volume: 72, P: 539-544
Larger core size has superior technical and analytical accuracy in bladder tissue microarray

Adel RH Eskaros
Shanna A Arnold Egloff
Andries Zijlstra
Research23 Jan 2017
Laboratory Investigation

Volume: 97, P: 335-342
Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation

Cpt1a-dependent fatty acid beta-oxidation is found to regulate neutrophil trafficking to the site of infection in a mouse model of pneumonia and is found to play a role in pneumonia susceptibility in humans.

Ly Pham
Padmini Komalavilas
Michael J. Noto
ResearchOpen Access13 Dec 2022
Communications Biology

Volume: 5, P: 1-13
Genomic control of inflammation in experimental atopic dermatitis

Yan Liu
Jozef Zienkiewicz
Jacek Hawiger
ResearchOpen Access07 Nov 2022
Scientific Reports

Volume: 12, P: 1-11
Hyperlipidemic hypersensitivity to lethal microbial inflammation and its reversal by selective targeting of nuclear transport shuttles

Yan Liu
Jozef Zienkiewicz
Jacek Hawiger
ResearchOpen Access07 Jun 2021
Scientific Reports

Volume: 11, P: 1-17
Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein Receptor^−/− Mice Improves Indices of Cardiometabolic Disease

Linda S. May-Zhang
Zhongyi Chen
Sean S. Davies
ResearchOpen Access23 Jan 2019
Scientific Reports

Volume: 9, P: 1-13
Tissue-specific expression of p73 and p63 isoforms in human tissues

Clayton B. Marshall
J. Scott Beeler
Jennifer A. Pietenpol
ResearchOpen Access27 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-10
Genomic landscape of a metastatic malignant proliferating tricholemmal tumor and its response to PI3K inhibition

Jean-Nicolas Gallant
Andrew Sewell
Christine M. Lovly
ResearchOpen Access15 Feb 2019
npj Precision Oncology

Volume: 3, P: 1-9

Search

Dietary zinc deficiency promotes Acinetobacter baumannii lung infection via IL-13 in mice

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

The receptor S1P₁ overrides regulatory T cell–mediated immune suppression through Akt-mTOR

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

No observed association for mitochondrial SNPs with preterm delivery and related outcomes

Larger core size has superior technical and analytical accuracy in bladder tissue microarray

Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation

Genomic control of inflammation in experimental atopic dermatitis

Hyperlipidemic hypersensitivity to lethal microbial inflammation and its reversal by selective targeting of nuclear transport shuttles

Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein Receptor^−/− Mice Improves Indices of Cardiometabolic Disease

Tissue-specific expression of p73 and p63 isoforms in human tissues

Genomic landscape of a metastatic malignant proliferating tricholemmal tumor and its response to PI3K inhibition

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