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Showing 1–5 of 5 results

Advanced filters: Author: Ken Halvorsen Clear advanced filters

High-throughput single-molecule quantification of individual base stacking energies in nucleic acids

In this work, the authors use a centrifuge force microscope for high-throughput single-molecule experiments to elucidate stacking energies between individual bases of DNA.

Jibin Abraham Punnoose
Kevin J. Thomas
Ken Halvorsen
ResearchOpen Access06 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Multiplexed single-molecule force spectroscopy using a centrifuge

Single molecule force spectroscopy (SMFS) has limitations in throughput and the ability to repeatedly interrogate single bonds. Here the authors repurpose a benchtop centrifuge and use DNA nanoswitches to enable high throughput SMFS capable of repeatedly measuring forces of single molecular pairs.

Darren Yang
Andrew Ward
Wesley P. Wong
ResearchOpen Access17 Mar 2016
Nature Communications

Volume: 7, P: 1-7
DNA nanoswitches: a quantitative platform for gel-based biomolecular interaction analysis

A DNA nanoswitch platform enables inexpensive kinetic and thermodynamic analysis of a range of biomolecular interactions using a simple gel electrophoresis readout.

Mounir A Koussa
Ken Halvorsen
Wesley P Wong
Research08 Dec 2014
Nature Methods

Volume: 12, P: 123-126
Rapid one-step detection of SARS-CoV-2 RNA

A one-pot fluorescence-based assay detects SARS-CoV-2 RNA in under an hour with high sensitivity and sequence specificity.

Arun Richard Chandrasekaran
Lifeng Zhou
Ken Halvorsen
News & Views08 Dec 2020
Nature Biomedical Engineering

Volume: 4, P: 1123-1124
A guide to building a low-cost centrifuge force microscope module for single-molecule force experiments

This protocol describes how to design and build a centrifuge force microscope that is 3D printed to fit within an existing benchtop centrifuge and enables the simultaneous probing of hundreds to thousands of single-molecule interactions using tethered particles.

Jibin Abraham Punnoose
Andrew Hayden
Ken Halvorsen
Protocols30 Dec 2024
Nature Protocols

Volume: 20, P: 1951-1975