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Advanced filters: Author: Ken-Wing Lee Clear advanced filters

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Fusion proteins in cancers with low mutational burden represent functional neoantigens that elicit T cell activation and mediate responses to immunotherapy.

Wei Yang
Ken-Wing Lee
Luc G. T. Morris
Research22 Apr 2019
Nature Medicine

Volume: 25, P: 767-775
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy

Samstein et al. report that mutations in BRCA1 and BRCA2 result in distinct mutational genomic landscapes, effects on the tumor-immune microenvironment and response to immune checkpoint therapy.

Robert M. Samstein
Chirag Krishna
Nadeem Riaz
Research16 Nov 2020
Nature Cancer

Volume: 1, P: 1188-1203
Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions

Myoepithelial carcinoma (MECA) is a rare aggressive salivary gland cancer. Here, the authors analyze the genomic landscape of MECA and identify a high prevalence of oncogenic gene fusions, primarily PLAG1 fusions, highlighting TGFBR3-PLAG1 as a potential hallmark of MECA.

Martin G. Dalin
Nora Katabi
Luc G. T. Morris
ResearchOpen Access30 Oct 2017
Nature Communications

Volume: 8, P: 1-13