Targeted drug delivery in response to external stimuli is therapeutically desirable, but long-term drug retention at the target site after stimulation is turned off remains a challenge. Here, the authors present a targeted delivery strategy via irreversible aggregation of drug carriers in response to mild external heating by constructing two types of polymeric micelles with a thermo-responsive polymer shell based on N-isopropylacrylamide and incorporating alkyne and azide moieties, respectively.
- Sota Yamada
- Eita Sasaki
- Kenjiro Hanaoka
