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Showing 1–10 of 10 results
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  • Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

    • Cristian Pattaro
    • Alexander Teumer
    • Caroline S. Fox
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19

  • Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease with a substantial burden worldwide. In this Consensus Statement, a global multidisciplinary group of experts develop consensus statements and recommendations addressing a broad range of topics on NAFLD to raise awareness and spur action.

    • Jeffrey V. Lazarus
    • Henry E. Mark
    • Ming-Hua Zheng
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 60-78

  • A combination of animal studies, data from a clinical trial and insights from an observational cohort suggest that, in individuals with metabolic dysfunction-associated steatohepatitis, semaglutide improves liver histology by reverting patient proteomes to better mimic the proteome of individuals without the disease.

    • Maximilian Jara
    • Jenny Norlin
    • Lotte B. Knudsen
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 3128-3140

  • Reducing the stigma and discrimination that people living with liver conditions experience requires rethinking how diagnoses, diseases, etiologies and circumstances are perceived — a shift that begins with the language used to name and describe them.

    • Jeffrey V. Lazarus
    • Dana Ivancovsky Wajcman
    • Marcela Villota-Rivas
    Comments & Opinion
    Nature Medicine
    Volume: 31, P: 2109-2116

  • A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci influencing this trait. Enrichment analyses, fine-mapping and colocalization with gene expression in 47 tissues implicate the kidney and liver as key target organs and prioritize potential causal genes.

    • Adrienne Tin
    • Jonathan Marten
    • Anna Köttgen
    Research
    Nature Genetics
    Volume: 51, P: 1459-1474

  • In this Comment, we provide a strategic framework for what could and should be measured, across four domains, to optimize standards of care for multidisciplinary models of care in nonalcoholic fatty liver disease.

    • Alina M. Allen
    • Zobair M. Younossi
    • Jeffrey V. Lazarus
    Comments & Opinion
    Nature Reviews Gastroenterology & Hepatology
    Volume: 20, P: 626-627

  • There is a need for effective models of care for patients with non-alcoholic fatty liver disease (NAFLD). In this Expert Recommendation, Lazarus et al. discuss seven examples of comprehensive NAFLD models of care and produce eight recommendations aimed at policy-makers and practitioners.

    • Jeffrey V. Lazarus
    • Quentin M. Anstee
    • Jörn M. Schattenberg
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 18, P: 717-729

  • This Review describes the pathophysiological roles of peroxisome proliferator-activated receptors (PPARs) in nonalcoholic steatohepatitis and related metabolic diseases, and summarizes the preclinical and clinical data on the use of PPAR agonists to treat nonalcoholic steatohepatitis as part of a systemic metabolic disease.

    • Sven Francque
    • Gyongyi Szabo
    • Frank Tacke
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 18, P: 24-39