Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Kenneth N Goldie Clear advanced filters

  • The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

    • Alex G. Contreras
    • Skylar Walters
    • Timothy J. Hohman
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • YenTcA is the pore-forming and membrane binding subunit of the ABC toxin YenTc, which is produced by the insect pathogen Yersinia entomophaga. Here authors present cryo-EM structures of YenTcA purified from the native source which implicate associated endochitinases in host cell recognition.

    • Sarah J Piper
    • Lou Brillault
    • Michael J Landsberg
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Much of the intracellular protein degradation in eukaryotes is controlled by cullin–RING ubiquitin ligases (CRLs), a vast class of enzymes which are regulated by the COP9 signalosome (CSN); structural characterization of CSN–N8CRL4A complexes by cryo-electron microscopy reveals an induced-fit mechanism of CSN activation triggered only by catalytically activated CRLs without bound substrate, explaining how CSN acts as a global regulator of CRLs.

    • Simone Cavadini
    • Eric S. Fischer
    • Nicolas H. Thomä
    Research
    Nature
    Volume: 531, P: 598-603

  • Using three-dimensional correlative light and electron microscopy of Lewy bodies and Lewy neurites in postmortem brains of Parkinson’s disease patients, researchers show that the major constituents are membranes rather than proteinaceous filaments.

    • Sarah H. Shahmoradian
    • Amanda J. Lewis
    • Matthias E. Lauer
    Research
    Nature Neuroscience
    Volume: 22, P: 1099-1109

  • The structure of the extended sheath–tube complex of the type VI secretion system from Vibrio cholerae elucidates the molecular mechanisms by which conformational changes in the sheath enable the inner tube to penetrate target cells.The structure of the extended sheath–tube complex of the type VI secretion system from Vibrio cholerae elucidates the molecular mechanisms by which conformational changes in the sheath enable the inner tube to penetrate target cells.

    • Jing Wang
    • Maximilian Brackmann
    • Marek Basler
    Research
    Nature Microbiology
    Volume: 2, P: 1507-1512