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Showing 1–4 of 4 results
Advanced filters: Author: Kenny Bravo-Rodriguez Clear advanced filters

  • Rare mutations in the high requirement temperature protein A1 (HTRA1) cause cerebral vasculopathy. Here, authors establish mechanistically distinct protein repair approaches to reverse the deleterious effects of pathogenic mutations interfering with the assembly and protease function of HTRA1.

    • Nathalie Beaufort
    • Linda Ingendahl
    • Martin Dichgans
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Current strategies for protein encapsulation in DNA vessels for controlled enzymatic catalysis or therapeutic delivery rely on formation of covalent complexes. Here, the authors design a system that mimics natural reversible non-covalent host–guest interactions between a DNA host and the protein DegP.

    • Andreas Sprengel
    • Pascal Lill
    • Barbara Saccà
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins on the disassembly of the p97 complex.

    • Anup Arumughan
    • Yvette Roske
    • Erich E. Wanker
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • A molecular tweezer has been shown to bind to the surface of a 14-3-3 protein through a particular lysine residue. This interaction — characterized in detail by protein crystallography and computational modelling — disrupts the protein's binding with partner proteins. These findings ascertain supramolecular chemistry as an enticing tool in chemical biology, here towards modulating protein functions.

    • David Bier
    • Rolf Rose
    • Christian Ottmann
    Research
    Nature Chemistry
    Volume: 5, P: 234-239