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Showing 1–4 of 4 results
Advanced filters: Author: Kent Kirshenbaum Clear advanced filters

  • Chemists have established numerous methods for performing protein conjugations, but metathesis catalysts have largely remained absent from this toolkit. Evidence that proteins bearing allylsulfides undergo cross-metathesis with chosen alkenes in aqueous conditions will allow chemists to harness the power of metathesis catalysts for modifying biomolecules and other water-soluble compounds.

    • Kent Kirshenbaum
    • Paramjit S Arora
    News & Views
    Nature Chemical Biology
    Volume: 4, P: 527-528

  • Elevated protein synthesis, and dysregulated mGluR signalling, are documented in fragile X syndrome (FXS) Here the authors use proteomic analysis in a mouse model of FXS, and following mGluR5 stimulation, to identify potential biomarkers for the disease.

    • Heather Bowling
    • Aditi Bhattacharya
    • Eric Klann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.

    • Jeffrey A. Schneider
    • Timothy W. Craven
    • Susan K. Logan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Protein nanoparticles derived from viruses are commonly studied, but a new rod-shaped thermophilic virus isolated from acidic hot springs may yield another class of protein building blocks that are stable and can be selectively modified with diverse chemical groups.

    • Isaac S. Carrico
    • Kent Kirshenbaum
    News & Views
    Nature Nanotechnology
    Volume: 4, P: 14-15