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Neuronal enhancers are hotspots for DNA single-strand break repair

DNA single-strand breaks in neurons accumulate at high levelsin functional enhancers.

Wei Wu
Sarah E. Kargbo-Hill
André Nussenzweig
Research25 Mar 2021
Nature

Volume: 593, P: 440-444
Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

Bach2 limits T cell effector functions. Here the authors show that Bach2–Batf complex antagonizes the recruitment of the Batf–Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production, and describe mechanisms of negative feedback by which Bach2 restricts Baft-mediated Th2 response.

Makoto Kuwahara
Wataru Ise
Masakatsu Yamashita
ResearchOpen Access01 Sept 2016
Nature Communications

Volume: 7, P: 1-13
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells

Although IFNγ is a Th1 signature cytokine and is repressed in Th2 cells, it is reactivated in a subset of memory Th2 cells. Here the authors show that Hdac2 is released from Gata3 by Akt-mediated phosphorylation, leading to transcriptional derepression of Tbx21 and IFN_γin these cells.

Hiroyuki Hosokawa
Tomoaki Tanaka
Toshinori Nakayama
ResearchOpen Access07 Apr 2016
Nature Communications

Volume: 7, P: 1-12
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T_H2 differentiation

The mechanisms of TGF-β-mediated inhibition of T_H2 differentiation remain unclear. Nakayama and colleagues show that TGF-β induces the transcription factor Sox4, which negatively regulates the transcription factor GATA-3 by two independent mechanisms.

Makoto Kuwahara
Masakatsu Yamashita
Toshinori Nakayama
Research01 Jul 2012
Nature Immunology

Volume: 13, P: 778-786
A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus

Kenta Inomata
Kazuki Tajima
Yuko Kitagawa
ResearchOpen Access09 Oct 2018
Scientific Reports

Volume: 8, P: 1-12

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Neuronal enhancers are hotspots for DNA single-strand break repair

Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus

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The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T_H2 differentiation