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Showing 1–10 of 10 results

Advanced filters: Author: Kentaro Takai Clear advanced filters

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

TLR7 triggers immune responses upon sensing microbial RNA, and its endosomal localization is thought to prevent TLR7 activation by host RNA. Here, Kanno et al. show that TLR7 is also present on the surface of immune cells, and that anti-TLR7 antibody can prevent TLR7-mediated autoimmunity.

Atsuo Kanno
Natsuko Tanimura
Kensuke Miyake
Research04 Feb 2015
Nature Communications

Volume: 6, P: 1-12
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Sex differences in brainstem structure volumes in patients with schizophrenia

Shintaro Aoyama
Hiroto Okuda
Kazutaka Ohi
ResearchOpen Access18 Mar 2023
Schizophrenia

Volume: 9, P: 1-3
The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B

Kizuki Watanabe
Shin-ya Nishio
Shunsuke Kondo
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-19
Shared genetic basis between reproductive behaviors and anxiety-related disorders

Kazutaka Ohi
Ayumi Kuramitsu
Toshiki Shioiri
Research24 Jun 2022
Molecular Psychiatry

Volume: 27, P: 4103-4112
Dual energy metabolism of the Campylobacterota endosymbiont in the chemosynthetic snail Alviniconcha marisindica

Junichi Miyazaki
Tetsuro Ikuta
Ken Takai
ResearchOpen Access12 Feb 2020
The ISME Journal

Volume: 14, P: 1273-1289
Clinical features and genetic mechanisms of anxiety, fear, and avoidance: A comprehensive review of five anxiety disorders

Kazutaka Ohi
Daisuke Fujikane
Toshiki Shioiri
ReviewsOpen Access19 Aug 2025
Molecular Psychiatry

Volume: 30, P: 4928-4936
Disruption of cell-type-specific methylation at the Maspin gene promoter is frequently involved in undifferentiated thyroid cancers

Satoshi Ogasawara
Chihaya Maesawa
Tomoyuki Masuda
Research05 Feb 2004
Oncogene

Volume: 23, P: 1117-1124
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes

Yuta Takahashi
Masao Ueki
Hiroaki Tomita
ResearchOpen Access17 Aug 2020
Translational Psychiatry

Volume: 10, P: 1-11