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Advanced filters: Author: Kequan Lin Clear advanced filters

Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneous insulin receptor endocytosis

Insulin signaling pathway is critical for glucose homeostasis maintenance. Here, the authors identify a role for DNAJA2 in regulating insulin signaling and glucose metabolism, loss of which causes insulin resistance and type 2 diabetes phenotypes.

Yuanhua Qin
Wenjun Wu
Yaping Huang
ResearchOpen Access13 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress

A loss-of-function screen reveals a role for lncRNA DARS-AS1 in promoting cancer cell proliferation and further experiments shows DARS-AS1 regulates the PACT-PKR pathway, overall suggesting it as a potential target for cancer therapy and prognosis.

Liuqing Yang
Kequan Lin
Dong Wang
ResearchOpen Access15 Aug 2022
Communications Biology

Volume: 5, P: 1-13
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer

Shuaishuai Teng
Yang Eric Li
Dong Wang
Research06 Dec 2019
Cell Research

Volume: 30, P: 34-49