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Showing 1–4 of 4 results

Advanced filters: Author: Kerim Babaoglu Clear advanced filters

Deconstructing fragment-based inhibitor discovery

Kerim Babaoglu
Brian K Shoichet
Research29 Oct 2006
Nature Chemical Biology

Volume: 2, P: 720-723
Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii

Antibiotics to treat carbapenem-resistant Acinetobacter baumannii infection are an urgent need. The cerastecins are potent, bactericidal and efficacious in animal models of infection, and may enable new treatment modalities targeting LOS transport.

Hao Wang
Andrii Ishchenko
Scott S. Walker
Research22 Apr 2024
Nature Microbiology

Volume: 9, P: 1244-1255
Structural basis for selectivity and diversity in angiotensin II receptors

Crystal structures of two complexes of the angiotensin II receptor AT₂R with distinct tightly bound ligands reveal an active-like state of the receptor, in which helix VIII adopts a non-canonical position that blocks binding of G proteins and β-arrestins.

Haitao Zhang
Gye Won Han
Vadim Cherezov
Research05 Apr 2017
Nature

Volume: 544, P: 327-332
Structure and ligand-binding mechanism of the human OX₁ and OX₂ orexin receptors

Human orexin receptors (hOX₁R and hOX₂R) are GPCRs involved in sleep regulation. Structures of hOX₁R bound to a selective antagonist or to a dual antagonist, functional assays and computational analyses reveal the basis for subtype selectivity.

Jie Yin
Kerim Babaoglu
Daniel M Rosenbaum
Research07 Mar 2016
Nature Structural & Molecular Biology

Volume: 23, P: 293-299