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Nature Communications (4)

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Showing 1–4 of 4 results

Advanced filters: Author: Kerstin Overkamp Clear advanced filters

Direct detection of an NH-π hydrogen bond in an intrinsically disordered peptide

The authors demonstrate a proof-of-principle example of an NH-π hydrogen bond on the surface of an intrinsically disordered protein through detection of weak scalar couplings by NMR, supported by Molecular Dynamics simulation and DFT calculations.

Luigi Russo
Dipendu Dhar
Nasrollah Rezaei-Ghaleh
ResearchOpen Access20 Nov 2025
Nature Communications

Volume: 16, P: 1-11
Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

This study characterizes the interaction between the clinical candidate anle138b and Aβ₄₀ fibrils in a lipid environment. The compound reduced fibril formation by approximately 75%, providing insights relevant to Alzheimer’s drug development.

Mookyoung Han
Benedikt Frieg
Christian Griesinger
ResearchOpen Access03 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Large dynamics of a phase separating arginine-glycine-rich domain revealed via nuclear and electron spins

The authors show the RNA-induced droplet formation by a component of Cajal bodies and reveal the large nanoseconds mobility of glycine residues inside droplets as a molecular factor potentially contributing to the large dynamics of Cajal bodies.

Giuseppe Sicoli
Daniel Sieme
Nasrollah Rezaei-Ghaleh
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-12
A litmus test for classifying recognition mechanisms of transiently binding proteins

The authors provide a litmus test for the recognition mechanism of transiently binding proteins based on nuclear magnetic resonance and find a conformational selection binding mechanism through concentration-dependent kinetics of ubiquitin and SH3.

Kalyan S. Chakrabarti
Simon Olsson
Christian Griesinger
ResearchOpen Access01 Jul 2022
Nature Communications

Volume: 13, P: 1-11