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Showing 1–4 of 4 results
Advanced filters: Author: Kevin B. Einkauf Clear advanced filters

  • A proteogenomic profiling analysis of single cells from the blood and lymph nodes of individuals living with HIV-1 reveals that CD4+ memory T cells harbouring intact provirus show signatures associated with resistance to immune-mediated killing and cell survival.

    • Weiwei Sun
    • Ce Gao
    • Mathias Lichterfeld
    ResearchOpen Access
    Nature
    Volume: 614, P: 309-317

  • In individuals who have achieved natural control of HIV-1 without drug treatment, intact proviral sequences are integrated into genomic regions that are not permissive to active viral transcription, indicating deep latency of the virus.

    • Chenyang Jiang
    • Xiaodong Lian
    • Xu G. Yu
    Research
    Nature
    Volume: 585, P: 261-267

  • The dynamics of HIV-1 DNA sequences early after HIV-1 transmission remains poorly characterized. Here, the authors perform a longitudinal evaluation of HIV-1 DNA sequences in subtype C-infected individuals during acute infection, providing a landscape of the nature and evolution of the very early viral genome.

    • Guinevere Q. Lee
    • Kavidha Reddy
    • Mathias Lichterfeld
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.

    • Jesse Fajnzylber
    • James Regan
    • Alex Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9