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Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

Nathaniel R West
Ahmed N Hegazy
Fiona Powrie
Amendments and Corrections06 Jun 2017
Nature Medicine

Volume: 23, P: 788
Fueling regulation: IL-2 keeps CD4⁺ T_reg cells fit

Naturally occurring regulatory T cells are key in controlling autoimmune and inflammatory responses. New data indicate that although interleukin 2 signals are not essential for regulatory T cell development in the thymus, they are critical for maintenance of these cells in the periphery.

Kevin J Maloy
Fiona Powrie
News & Views01 Nov 2005
Nature Immunology

Volume: 6, P: 1071-1072
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

The cytokine interleukin (IL)-23 has inflammatory effects on innate immune cells and can drive colitis, but the cellular and molecular pathways involved are poorly characterized. Here it is shown that bacterial-driven innate colitis involves a previously unknown population of IL-23-responsive innate leukocytes that produce IL-17 and interferon-γ. These cells may represent a target in inflammatory bowel disease.

Sofia Buonocore
Philip P. Ahern
Fiona Powrie
Research15 Apr 2010
Nature

Volume: 464, P: 1371-1375
Barrier regulation: tolerance stops at cell death

The accumulation of intestinal Foxp3⁺ regulatory T cells (T_reg cells) in response to the microbiota is tightly regulated. Epithelial apoptosis inhibits the production of tolerogenic interferon-β by myeloid cells and thereby reduces the frequency of T_reg cells and lowers the threshold for inflammatory responses.

Johanna Pott
Kevin J Maloy
Ana Izcue
News & Views22 Mar 2016
Nature Immunology

Volume: 17, P: 349-350
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

The cytokine oncostatin M drives intestinal inflammation in mice, and its abundance in the intestine of patients with inflammatory bowel disease predicts response to tumor necrosis factor–neutralizing therapy.

Nathaniel R West
Ahmed N Hegazy
Fiona Powrie
Research03 Apr 2017
Nature Medicine

Volume: 23, P: 579-589
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

The International Mouse Phenotyping Consortium (IMPC) aims to identify the function of all protein-coding genes in the mouse genome. Hayday and colleagues leverage 530 knockout lines from the IPMC to develop the 3i Project, which immunophenotypes mice and leads to the identification of new and unexpected gene influences on immune function and on the structural organization of the immune system.

Lucie Abeler-Dörner
Adam G. Laing
Adrian C. Hayday
Research16 Dec 2019
Nature Immunology

Volume: 21, P: 86-100
Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis

Large-scale gut microbiome analysis of a widely use mouse model of inflammatory bowel disease reveals that the gut microbiome is a driver of variability across genetically identical mice, in particular two species that are associated with variable treatment endpoints.

Samuel C. Forster
Simon Clare
Trevor D. Lawley
ResearchOpen Access01 Apr 2022
Nature Microbiology

Volume: 7, P: 590-599
Intestinal homeostasis and its breakdown in inflammatory bowel disease

Kevin J. Maloy
Fiona Powrie
Reviews15 Jun 2011
Nature

Volume: 474, P: 298-306
Regulatory T cells in the control of immune pathology

Kevin J. Maloy
Fiona Powrie
Reviews01 Sept 2001
Nature Immunology

Volume: 2, P: 816-822
Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3⁺ Treg cell function in the intestine

O J Harrison
N Srinivasan
K J Maloy
Research04 Mar 2015
Mucosal Immunology

Volume: 8, P: 1226-1236
Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen

G X Song-Zhao
N Srinivasan
K J Maloy
Research27 Nov 2013
Mucosal Immunology

Volume: 7, P: 763-774
NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen

S Nordlander
J Pott
K J Maloy
Research27 Nov 2013
Mucosal Immunology

Volume: 7, P: 775-785
Pretransplant comprehensive geriatric assessment in hematopoietic cell transplantation: a single center experience

Richard J. Lin
Armin Shahrokni
Sergio A. Giralt
Correspondence09 Mar 2018
Bone Marrow Transplantation

Volume: 53, P: 1184-1187
IL-23 and Th17 cytokines in intestinal homeostasis

K J Maloy
M C Kullberg
Reviews02 Jul 2008
Mucosal Immunology

Volume: 1, P: 339-349

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