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Showing 1–9 of 9 results
Advanced filters: Author: Kevin L. Briggman Clear advanced filters

  • To date, various aspects of connectivity have been inferred from electron microscopy (EM) of synaptic contacts, light microscopy of axonal and dendritic arbors, and correlations in activity. However, until now it has not been possible to relate the complex structural wiring between neurons to the function of individual cells. Using a combination of functional imaging and three-dimensional serial EM reconstruction at unprecedented scale, two papers now describe the connectivity of single cells in the mouse visual system. This study examines how the selectivity of directionally selective retinal ganglion cells may arise from their asymmetry in the wiring with amacrine cells.

    • Kevin L. Briggman
    • Moritz Helmstaedter
    • Winfried Denk
    Research
    Nature
    Volume: 471, P: 183-188

  • Directional selectivity in the detection of moving visual stimuli critically depends on starburst amacrine cells, which have been studied primarily in rabbit retina; a large-scale reconstruction of the mouse retina at a single-synapse level, along with experimental and theoretical analysis, shows that mouse retinal circuitry is adapted to the smaller eye size of mice.

    • Huayu Ding
    • Robert G. Smith
    • Kevin L. Briggman
    Research
    Nature
    Volume: 535, P: 105-110

  • In recent decades, advances in technology have enabled the structure of the nervous system to be dissected in greater detail than ever before. In this Opinion article, Denk and colleagues outline why structural information is so important for our understanding of the function of neural circuits and describe new tools and approaches that are improving the structural information that we can acquire.

    • Winfried Denk
    • Kevin L. Briggman
    • Moritz Helmstaedter
    Reviews
    Nature Reviews Neuroscience
    Volume: 13, P: 351-358

  • Spectrally resolved photoacoustic images often require the acquisition of data for each wavelength separately. Here, the authors use dual frequency-comb spectroscopy for photoacoustic measurements, enabling spectrally resolved measurements without the need to scan the illumination wavelength.

    • Jacob T. Friedlein
    • Esther Baumann
    • Kevin C. Cossel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Improved electron microscopy methods are used to map a mammalian retinal circuit of close to 1,000 neurons; the work reveals a new type of retinal bipolar neuron and suggests functional mechanisms for known visual computations.

    • Moritz Helmstaedter
    • Kevin L. Briggman
    • Winfried Denk
    Research
    Nature
    Volume: 500, P: 168-174

  • The mechanisms of contextual modulation in direction selective ganglion cells in the retina remain unclear. Here, the authors find that that On-Off direction-selective ganglion cells are differentially sensitive to discontinuities of dark and bright moving edges in the visual environment and, using synapse-specific genetic manipulations with functional measurements, reveal the microcircuits underlying this contextual sensitivity.

    • Xiaolin Huang
    • Melissa Rangel
    • Wei Wei
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Volume electron microscopy of retinas from two birds living in different habitats sheds light on species-specific wiring differences of double cone contacting bipolar cells and identifies principal and accessory member specific downstream circuits.

    • Anja Günther
    • Silke Haverkamp
    • Kevin L. Briggman
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-11

  • This Technical Report describes an automated algorithm to trace densely labeled neurons and reconstruct their structure, thus providing a new tool in functional connectome analysis.

    • Moritz Helmstaedter
    • Kevin L Briggman
    • Winfried Denk
    Research
    Nature Neuroscience
    Volume: 14, P: 1081-1088