Nature Search

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Zhong Wang
Kevin S. Smith
Michael L. Cleary
Research17 Sept 2008
Nature

Volume: 455, P: 1205-1209
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Suppressing quantum errors by scaling a surface code logical qubit

A study demonstrating increasing error suppression with larger surface code logical qubits, implemented on a superconducting quantum processor.

Rajeev Acharya
Igor Aleiner
Ningfeng Zhu
ResearchOpen Access22 Feb 2023
Nature

Volume: 614, P: 676-681
Two susceptibility loci identified for prostate cancer aggressiveness

Prostate cancer often does not progress to invasive disease and thus markers predicting the course of the disease progression are critical for optimal treatment choices. Here the authors show that variants at two genetic loci correlate with the aggressiveness of prostate cancer.

Sonja I. Berndt
Zhaoming Wang
Stephen J. Chanock
Research05 May 2015
Nature Communications

Volume: 6, P: 1-7
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

A systematic review of evidence, across the key pillars of prevention, diagnosis, treatment and prognosis, outlines milestones that need to be met to enable the broad clinical implementation of precision medicine in diabetes care.

Deirdre K. Tobias
Jordi Merino
Paul W. Franks
Reviews05 Oct 2023
Nature Medicine

Volume: 29, P: 2438-2457
Live Birth in Sex-Reversed XY Mice Lacking the Nuclear Receptor Dax1

Isabel Fernandes-Freitas
Alexandra Milona
Bryn M. Owen
ResearchOpen Access03 Feb 2020
Scientific Reports

Volume: 10, P: 1-6
Determining crystal structures through crowdsourcing and coursework

Building crystal structures into the electron density is an important step in protein structure solution. Here, the authors recruit online game players, students, and experienced crystallographers to compete in a competition to solve a new structure, and find that crowdsourcing model-building works.

Scott Horowitz
Brian Koepnick
James C. A. Bardwell
ResearchOpen Access16 Sept 2016
Nature Communications

Volume: 7, P: 1-11
Exponential suppression of bit or phase errors with cyclic error correction

Repetition codes running many cycles of quantum error correction achieve exponential suppression of errors with increasing numbers of qubits.

Zijun Chen
Kevin J. Satzinger
Julian Kelly
ResearchOpen Access14 Jul 2021
Nature

Volume: 595, P: 383-387
Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage

This Resource describes data, code and tools developed for the Human Reference Atlas and the Human BioMolecular Atlas Program for building and navigating a multiscale human atlas.

Katy Börner
Philip D. Blood
Bruce W. Herr II
ResearchOpen Access13 Mar 2025
Nature Methods

Volume: 22, P: 845-860
cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing

Mutations in LSM11 and RNU7-1, which encode components of the replication-dependent histone pre-mRNA–processing complex, cause an autoinflammatory syndrome due to enhanced interferon signaling mediated by the cGAS–STING pathway, showing an essential role for nuclear histones in suppressing the immunogenicity of self-DNA.

Carolina Uggenti
Alice Lepelley
Yanick J. Crow
Research23 Nov 2020
Nature Genetics

Volume: 52, P: 1364-1372
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.

Filippo Veglia
Vladimir A. Tyurin
Dmitry I. Gabrilovich
ResearchOpen Access14 Dec 2017
Nature Communications

Volume: 8, P: 1-16
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Epitaxial graphene quantum dots for high-performance terahertz bolometers

Bolometers with high responsivity and low electrical noise can be fabricated exploiting the conductance gap induced in graphene quantum dots by quantum confinement and their interaction with the substrate.

Abdel El Fatimy
Rachael L. Myers-Ward
Paola Barbara
Research04 Jan 2016
Nature Nanotechnology

Volume: 11, P: 335-338
Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Amendments and Corrections13 Feb 2023
Nature Genetics

Volume: 55, P: 519-520
Author Correction: CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Nathan T. Ross
Felix Lohmann
Rohan E. J. Beckwith
Amendments and Corrections04 Mar 2020
Nature Chemical Biology

Volume: 16, P: 479
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Two doses of the coronavirus disease 2019 vaccine ChAdOx1 nCoV-19 boost antibody responses and functions in phase 1/2 trial participants.

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 279-288
Bellybutton: accessible and customizable deep-learning image segmentation

Sam Dillavou
Jesse M. Hanlan
Douglas J. Durian
ResearchOpen Access20 Jun 2024
Scientific Reports

Volume: 14, P: 1-7
Deep learning is combined with massive-scale citizen science to improve large-scale image classification

Pattern recognition in imaging data by >300,000 players of a global, online, commercial computer game is combined with deep learning to improve the accuracy of annotation of subcellular protein localization.

Devin P Sullivan
Casper F Winsnes
Emma Lundberg
Research20 Aug 2018
Nature Biotechnology

Volume: 36, P: 820-828
Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis

Grieger, Takele, Vesco, et al. perform a systematic review and meta-analysis of gestational weight gain interventions. Findings indicate lifestyle interventions that reduce excessive gestational weight gain provide greater benefits for women with a normal BMI and higher HDL cholesterol levels at the initiation of interventions.

Jessica A. Grieger
Wubet Worku Takele
Siew Lim
ResearchOpen Access24 Oct 2025
Communications Medicine

Volume: 5, P: 1-13
Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Defective ribonucleotide excision repair causes ID4, an indel cancer signature characterized by deletions of 2–5 base pairs.

Martin A. M. Reijns
David A. Parry
Andrew P. Jackson
ResearchOpen Access09 Feb 2022
Nature

Volume: 602, P: 623-631
Combining genomic and epidemiological data to compare the transmissibility of SARS-CoV-2 variants Alpha and Iota

The Alpha and Iota SARS-CoV-2 variants exhibit up to 50% greater transmissibility compared to other circulating variants in Connecticut in early 2021.

Mary E. Petrone
Jessica E. Rothman
Nathan D. Grubaugh
ResearchOpen Access11 May 2022
Communications Biology

Volume: 5, P: 1-10
Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution

Cleared-tissue axially swept light-sheet microscopy (ctASLM) enables high-speed, refraction index-independent imaging of live, cleared and expanded samples with isotropic, submicron resolution.

Tonmoy Chakraborty
Meghan K. Driscoll
Reto Fiolka
Research31 Oct 2019
Nature Methods

Volume: 16, P: 1109-1113
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

Tait and colleagues show that caspase-independent cell death induced by mitochondrial permeabilization stimulates NF-κB activity through downregulation of inhibitor of apoptosis, and enhances anti-tumour effects.

Evangelos Giampazolias
Barbara Zunino
Stephen W. G. Tait
Research28 Aug 2017
Nature Cell Biology

Volume: 19, P: 1116-1129
KBase: The United States Department of Energy Systems Biology Knowledgebase

Adam P Arkin
Robert W Cottingham
Dantong Yu
CorrespondenceOpen Access06 Jul 2018
Nature Biotechnology

Volume: 36, P: 566-569
THE SPECTRUM OF PULMONARY VASCULAR DISEASE IN INFANTS AND CHILDREN WITH CARDIOMYOPATHY

Anne M Murphy
David Witte
Samuel Kaplan
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 192
Evolution of chaperome gene expression and regulatory elements in the antarctic notothenioid fishes

Kevin T. Bilyk
Xuan Zhuang
C-H Christina Cheng
Research05 Nov 2020
Heredity

Volume: 126, P: 424-441
Are all fats created equal?

The interplay of factors that impair insulin signaling to cause type 2 diabetes is unclear, but one idea is that visceral fat might produce them. Visfatin, a protein previously known for its effect on immune cells, may be one of these factors.

Kevin G Murphy
Stephen R Bloom
News & Views01 Jan 2006
Nature Medicine

Volume: 12, P: 32-33
A comprehensive assessment of p53-responsive genes following adenoviral-p53 gene transfer in Bcl-2-expressing prostate cancer cells

Kevin B Spurgers
Kevin R Coombes
Timothy J McDonnell
Research01 Dec 2003
Oncogene

Volume: 23, P: 1712-1723
Platelet Binding Characteristics Distinguish Placebo Responders from Nonresponders in Depression

Yvette I Sheline
Kevin J Black
John G Csernansky
Research01 Jul 1995
Neuropsychopharmacology

Volume: 12, P: 315-322
Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis

F M Lyng
C B Seymour
C Mothersill
ResearchOpen Access10 Oct 2000
British Journal of Cancer

Volume: 83, P: 1223-1230
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

Stevens and colleagues show that human stem-cell-differentiated microglia can be used to model the extensive transcriptional diversity of human brain microglia.

Michael-John Dolan
Martine Therrien
Beth Stevens
ResearchOpen Access27 Jul 2023
Nature Immunology

Volume: 24, P: 1382-1390
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Retinal Structures and Visual Cortex Activity are Impaired Prior to Clinical Vision Loss in Glaucoma

Matthew C. Murphy
Ian P. Conner
Kevin C. Chan
ResearchOpen Access11 Aug 2016
Scientific Reports

Volume: 6, P: 1-11
Correction: Corrigendum: Determining crystal structures through crowdsourcing and coursework

Scott Horowitz
Brian Koepnick
James C. A. Bardwell
Amendments and CorrectionsOpen Access25 Oct 2016
Nature Communications

Volume: 7, P: 1-2
Cerebrovascular reactivity in multiple sclerosis is restored with reduced inflammation during immunomodulation

Antonio Maria Chiarelli
Alessandro Villani
Valentina Tomassini
ResearchOpen Access14 Sept 2022
Scientific Reports

Volume: 12, P: 1-11
Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts

A diagnostic tool based on blood RNA-seq is shown to identify causal genes and variants linked to clinical phenotypes in individuals with rare diseases for which whole-exome genetic sequencing was uninformative.

Laure Frésard
Craig Smail
Stephen B. Montgomery
Research03 Jun 2019
Nature Medicine

Volume: 25, P: 911-919
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

This study establishes reciprocal regulation between the two key nutrient sensors in cells, mTORC1 and AMPK, showing that mTORC1 directly inhibits AMPK by phosphorylation at S345 in the AMPK catalytic subunit α2.

Naomi X. Y. Ling
Adrian Kaczmarek
Janni Petersen
Research20 Jan 2020
Nature Metabolism

Volume: 2, P: 41-49
Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Sanjay Jain
Liming Pei
Michael P. Snyder
Amendments and Corrections01 Mar 2024
Nature Cell Biology

Volume: 26, P: 839
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Amendments and Corrections06 May 2021
Nature Medicine

Volume: 27, P: 1113
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
De novo mutations in ATP1A3 cause alternating hemiplegia of childhood

David Goldstein, Mohamad Mikati and colleagues report identification of de novo mutations in ATP1A3 in alternating hemiplegia of childhood, which is a rare neurodevelopmental syndrome characterized by recurrent hemiplegic episodes and distinct neurologic manifestations.

Erin L Heinzen
Kathryn J Swoboda
David B Goldstein
Research29 Jul 2012
Nature Genetics

Volume: 44, P: 1030-1034
Effects of dyslipidaemia on monocyte production and function in cardiovascular disease

Accumulating evidence has challenged the dogma of monocytes as short-lived macrophage precursors. Monocyte populations are heterogeneous and have subset-specific functions. This Review provides an updated view of the role of monocytes in cardiovascular disease and their relationship with macrophages, highlighting current theories on monocyte ontogeny, and discussing the effects of dyslipidaemia on monocyte production, phenotype, and function.

Mohammed Shamim Rahman
Andrew J. Murphy
Kevin J. Woollard
Reviews16 Mar 2017
Nature Reviews Cardiology

Volume: 14, P: 387-400
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

Chiea C Khor
Stephen J Chapman
Adrian V S Hill
Research25 Feb 2007
Nature Genetics

Volume: 39, P: 523-528
Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size

Daqiang Sun
Christopher R. K. Ching
Carrie E. Bearden
ResearchOpen Access13 Jun 2018
Molecular Psychiatry

Volume: 25, P: 1822-1834
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Rachel L O’Connell
Tim Rattay
Mohammed Mustafa
ResearchOpen Access29 Mar 2019
British Journal of Cancer

Volume: 120, P: 883-895
Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion

Isabelle Cleynen
Worrawat Engchuan
Anne S. Bassett
Research03 Feb 2020
Molecular Psychiatry

Volume: 26, P: 4496-4510
Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study

Julio E. Villalón-Reina
Kenia Martínez
Carrie E. Bearden
ResearchOpen Access29 Jul 2019
Molecular Psychiatry

Volume: 25, P: 2818-2831
Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction

David Shahnazaryan
Rana Khalil
Conor C. Murphy
ResearchOpen Access17 Dec 2020
Scientific Reports

Volume: 10, P: 1-10

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