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Showing 1–27 of 27 results
Advanced filters: Author: Kevin W. Eliceiri Clear advanced filters

  • A neuron-specific isoform of PGC-1α is regulated independently from other isoforms and is repressed with age. Here, the authors show PGC-1α is central in a growth and metabolism networks directly relevant to brain aging.

    • Dylan C. Souder
    • Eric R. McGregor
    • Rozalyn M. Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • The sparse, noisy, and distorted raw photon data captured by single-photon cameras make it difficult to estimate scene properties under challenging illumination conditions. Here, the authors present Collaborative photon processing for Active Single-Photon Imaging (CASPI), a technology-agnostic, application-agnostic, and training-free photon processing pipeline for high-resolution single-photon cameras.

    • Jongho Lee
    • Atul Ingle
    • Mohit Gupta
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Intraoperative fluorescence enables highly specific real-time detection of tumours at the time of surgery. In particular, near-infrared (NIR) fluorescence is a promising tool currently being tested in clinical settings. Zhang et al. discuss the latest developments in NIR fluorophores, cancer-targeting strategies, and detection instrumentation for intraoperative cancer detection, as well as the challenges associated with their effective application in clinical settings.

    • Ray R. Zhang
    • Alexandra B. Schroeder
    • Jamey P. Weichert
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 14, P: 347-364

  • Imaging the mouse brain using glass cranial windows has limitations in terms of flexibility and long-term imaging. Here the authors engineer transparent polymer skulls that can fit various skull morphologies and can be implanted for over 300 days, enabling simultaneous high resolution brain imaging and electrophysiology across large cortical areas.

    • Leila Ghanbari
    • Russell E. Carter
    • Suhasa B. Kodandaramaiah
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Postpartum involution of the mammary gland is a recognized risk factor for breast cancer. This report identifies a mechanism that could be at least partially responsible for the increased risk, involving both the elevated expression of COX-2 and its interaction with extracellular collagen, the deposition of which occurs during postpartum involution. Both these factors promote tumor growth and invasion in mice and correlate with poor prognosis in young women with breast cancer. The data suggest that ibuprofen treatment during involution is a safe and effective approach to diminish pregnancy-associated cancer.

    • Traci R Lyons
    • Jenean O'Brien
    • Pepper Schedin
    Research
    Nature Medicine
    Volume: 17, P: 1109-1115

  • For the past 25 years NIH Image and ImageJ software have been pioneers as open tools for the analysis of scientific images. We discuss the origins, challenges and solutions of these two programs, and how their history can serve to advise and inform other software projects.

    • Caroline A Schneider
    • Wayne S Rasband
    • Kevin W Eliceiri
    Comments & Opinion
    Nature Methods
    Volume: 9, P: 671-675

  • Bioimaging software developed in a research setting often is not widely used by the scientific community. We suggest that, to maximize both the public's and researchers' investments, usability should be a more highly valued goal. We describe specific characteristics of usability toward which bioimaging software projects should aim.

    • Anne E Carpenter
    • Lee Kamentsky
    • Kevin W Eliceiri
    Comments & Opinion
    Nature Methods
    Volume: 9, P: 666-670

  • The language used by microscopists who wish to find and measure objects in an image often differs in critical ways from that used by computer scientists who create tools to help them do this, making communication hard across disciplines. This work proposes a set of standardized questions that can guide analyses and shows how it can improve the future of bioimage analysis as a whole by making image analysis workflows and tools more FAIR (findable, accessible, interoperable and reusable).

    • Beth A. Cimini
    • Kevin W. Eliceiri
    Comments & Opinion
    Nature Methods
    Volume: 20, P: 976-978

  • We dream of a future where light microscopes have new capabilities: language-guided image acquisition, automatic image analysis based on extensive prior training from biologist experts, and language-guided image analysis for custom analyses. Most capabilities have reached the proof-of-principle stage, but implementation would be accelerated by efforts to gather appropriate training sets and make user-friendly interfaces.

    • Anne E. Carpenter
    • Beth A. Cimini
    • Kevin W. Eliceiri
    Comments & Opinion
    Nature Methods
    Volume: 20, P: 962-964

  • Longmore and colleagues show that in cancer cells that have undergone epithelial-to-mesenchymal transition (EMT), activation of the collagen I receptor DDR2 results in ERK2-dependent maintenance of the protein levels and activity of the EMT inducer SNAIL1, thus facilitating cancer cell invasion and metastasis.

    • Kun Zhang
    • Callie A. Corsa
    • Gregory D. Longmore
    Research
    Nature Cell Biology
    Volume: 15, P: 677-687

  • Representative members of the bioimage informatics community review the computational steps and some of the primary software tools available to biologists who are acquiring and analyzing microscopy-based digital image data, with a focus on open-source options.

    • Kevin W Eliceiri
    • Michael R Berthold
    • Anne E Carpenter
    Reviews
    Nature Methods
    Volume: 9, P: 697-710

  • This Perspective reviews imaging technologies for 3D pathology, and the associated computational tools for image processing and interpretation.

    • Jonathan T. C. Liu
    • Adam K. Glaser
    • Anant Madabhushi
    Reviews
    Nature Biomedical Engineering
    Volume: 5, P: 203-218

  • Keikhosravi et al. utilises convolutional neural network (CNN) on standard H&E stained histology images to extract information about collagen fiber arrangement and alignment. Collagen images synthesized from CNN are very similar to true collagen maps produced via second harmonic generation (SHG) and other approaches.

    • Adib Keikhosravi
    • Bin Li
    • Kevin W. Eliceiri
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-12

  • Presented is an overview of the image-analysis software platform Fiji, a distribution of ImageJ that updates the underlying ImageJ architecture and adds modern software design elements to expand the capabilities of the platform and facilitate collaboration between biologists and computer scientists.

    • Johannes Schindelin
    • Ignacio Arganda-Carreras
    • Albert Cardona
    Reviews
    Nature Methods
    Volume: 9, P: 676-682