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Showing 1–4 of 4 results
Advanced filters: Author: Kewen Qian Clear advanced filters

  • SARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to ACE2, and determine pharmakocinetic parameters of ACE2-Ig in mice.

    • Changhai Lei
    • Kewen Qian
    • Shi Hu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-5

  • In this study, Qian et al. identify a crosstalk between branched-chain amino acid metabolism and cell growth and motility through RhoC. Their work shows how enhanced BCAT1 activity, as identified by a mutation enriched in gastric cancer, leads to increased production of a metabolite that activates RhoC signaling.

    • Lin Qian
    • Na Li
    • Qun-Ying Lei
    Research
    Nature Metabolism
    Volume: 5, P: 1159-1173

  • Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T cells) are a promising new treatment for cancer, but are associated with unique toxicities. Here, the authors test CAR-T-cell-derived exosomes as a surrogate for CAR-T cells and show that they can elicit a potent antitumour immune response in preclinical models of breast cancer with reduced signs of cytokine release syndrome compared with CAR-T therapy.

    • Wenyan Fu
    • Changhai Lei
    • Shi Hu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12