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Showing 1–3 of 3 results
Advanced filters: Author: Khadija Banu Clear advanced filters

  • Shroom3 genetic variants increase Shroom3 levels and promote kidney fibrosis but reduce proteinuria, complicating Shroom3 targeting for precision medicine. Here, the authors show increased fibrosis mediated by Shroom3–Rock signaling and blocking this interaction genetically or with new compounds reduces tubular Rock activation and fibrosis.

    • Anand Reghuvaran
    • Ashwani Kumar
    • Madhav C. Menon
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-21

  • The authors previously reported HCK was associated with kidney inflammation and fibrosis. Here, they further unravel a mechanism of HCK regulating autophagy within macrophages, altering their polarization, proliferation, and migration and they also developed a more selective HCK inhibitor.

    • Man Chen
    • Madhav C. Menon
    • Chengguo Wei
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • OrganEx—an extracorporeal pulsatile-perfusion system with cytoprotective perfusate for porcine whole-body settings—preserved tissue integrity, decreased cell death and restored selected molecular and cellular processes across multiple vital organs after 1 h of warm ischaemia in pigs.

    • David Andrijevic
    • Zvonimir Vrselja
    • Nenad Sestan
    Research
    Nature
    Volume: 608, P: 405-412