Autoinducer 2 (AI2) is the only quorum-sensing signal that is shared by Gram-negative and Gram-positive bacteria. Because AI2 biosynthesis, specified by theluxS gene, is linked to S-adenosyl homocysteine recycling, determining whether luxSbiofilm phenotypes are due to signalling or effects on bacterial metabolism is not straightforward, and is discussed here.
- Kim Rachael Hardie
- Karin Heurlier
