Nature Search

Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy

In this study, the authors generated iPSC lines from more than 100 sporadic ALS cases, which recapitulated key disease phenotypes and enabled large-scale drug screening, identifying a promising combination therapy of baricitinib, memantine and riluzole.

Christopher R. Bye
Elizabeth Qian
Bradley J. Turner
ResearchOpen Access24 Nov 2025
Nature Neuroscience

Volume: 29, P: 40-52
Steps toward mapping the human vasculature by phage display

Wadih Arap
Mikhail G. Kolonin
Renata Pasqualini
Research01 Feb 2002
Nature Medicine

Volume: 8, P: 121-127
Genome-wide characterization of the routes to pluripotency

This study presents an extensive molecular characterization of the reprograming process by analysis of transcriptomic, epigenomic and proteomic data sets describing the routes to pluripotency; it finds distinct routes towards two stable pluripotent states characterized by distinct epigenetic events.

Samer M. I. Hussein
Mira C. Puri
Andras Nagy
Research10 Dec 2014
Nature

Volume: 516, P: 198-206
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates expression of genes in cell cycle progression, maintaining genomic stability and tumour growth.

Virginia Giuliani
Meredith A. Miller
Timothy P. Heffernan
ResearchOpen Access30 Jul 2021
Nature Communications

Volume: 12, P: 1-19
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Fingerprinting the circulating repertoire of antibodies from cancer patients

Paul J. Mintz
Jeri Kim
Wadih Arap
Research23 Dec 2002
Nature Biotechnology

Volume: 21, P: 57-63
Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal

Danielle R. Bond
Sean M. Burnard
Heather J. Lee
ResearchOpen Access17 Jul 2025
Leukemia

Volume: 39, P: 2275-2280
Podocyte dysfunction driven by heme in sickle-cell nephropathy

Chloé Ben Ali
Antoine Morel
Carole Hénique
ResearchOpen Access25 Jul 2025
Scientific Reports

Volume: 15, P: 1-21
Benchmarking single cell RNA-sequencing analysis pipelines using mixture control experiments

A dataset made up of single cancer cells or their mixtures serves as a benchmark for testing almost 4,000 combinations of scRNA-seq data analysis methods.

Luyi Tian
Xueyi Dong
Matthew E. Ritchie
Research27 May 2019
Nature Methods

Volume: 16, P: 479-487
DynOmics to identify delays and co-expression patterns across time course experiments

Jasmin Straube
Bevan Emma Huang
Kim-Anh Lê Cao
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Biomarker development for axial spondyloarthritis

Biomarkers help in the diagnosis and monitoring of disease, but robust biomarkers can be difficult to discover and validate. This Review explores the state of biomarker discovery for axial spondyloarthritis and suggests future developments to advance this field.

Matthew A. Brown
Zhixiu Li
Kim-Anh Lê Cao
Reviews30 Jun 2020
Nature Reviews Rheumatology

Volume: 16, P: 448-463
Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing

CaptureSeq was used to quantitatively profile transcripts with low expression, resulting in a catalog of long noncoding RNA expression in 20 human tissues.

Michael B Clark
Tim R Mercer
Marcel E Dinger
Research09 Mar 2015
Nature Methods

Volume: 12, P: 339-342
Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Rashmi Kanagal-Shamanna
Attilio Orazi
Carlos Bueso-Ramos
Research13 Nov 2021
Modern Pathology

Volume: 35, P: 470-479
Personalized Integrated Network Modeling of the Cancer Proteome Atlas

Min Jin Ha
Sayantan Banerjee
Veerabhadran Baladandayuthapani
ResearchOpen Access08 Oct 2018
Scientific Reports

Volume: 8, P: 1-14
Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks’ gestation: a retrospective cohort study

Deepika Rustogi
Anne Synnes
Phil Murphy
Research25 May 2021
Journal of Perinatology

Volume: 41, P: 1313-1321
Correction to: Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Rashmi Kanagal-Shamanna
Attilio Orazi
Carlos Bueso-Ramos
Amendments and Corrections13 Dec 2021
Modern Pathology

Volume: 35, P: 705
Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes

Guillermo Montalban-Bravo
Caleb A. Class
Guillermo Garcia-Manero
Research12 Nov 2019
Leukemia

Volume: 34, P: 872-881
Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer

Chao Liu
Florian Rohart
Kim-Anh Lê Cao
ResearchOpen Access26 Sept 2016
Scientific Reports

Volume: 6, P: 1-11
Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia

Yue Wei
Rashmi Kanagal-Shamanna
Guillermo Garcia-Manero
Research14 Jun 2022
Leukemia

Volume: 36, P: 2097-2107
Microfluidic model of the platelet-generating organ: beyond bone marrow biomimetics

Antoine Blin
Anne Le Goff
Dominique Baruch
ResearchOpen Access22 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Disease surveillance based on Internet-based linear models: an Australian case study of previously unmodeled infection diseases

Florian Rohart
Gabriel J. Milinovich
Wenbiao Hu
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-11
Evolutionary action score identifies a subset of TP53 mutated myelodysplastic syndrome with favorable prognosis

Rashmi Kanagal-Shamanna
Guillermo Montalban-Bravo
Guillermo Garcia-Manero
CorrespondenceOpen Access06 Mar 2021
Blood Cancer Journal

Volume: 11, P: 1-5
Combined laser capture microdissection and serial analysis of gene expression from human tissue samples

Jeong Hee Cho-Vega
Patricia Troncoso
Timothy J McDonnell
Research29 Oct 2004
Modern Pathology

Volume: 18, P: 577-584

Search

Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy

Steps toward mapping the human vasculature by phage display

Genome-wide characterization of the routes to pluripotency

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Fingerprinting the circulating repertoire of antibodies from cancer patients

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal

Podocyte dysfunction driven by heme in sickle-cell nephropathy

Benchmarking single cell RNA-sequencing analysis pipelines using mixture control experiments

DynOmics to identify delays and co-expression patterns across time course experiments

Biomarker development for axial spondyloarthritis

Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing

Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Personalized Integrated Network Modeling of the Cancer Proteome Atlas

Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks’ gestation: a retrospective cohort study

Correction to: Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes

Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer

Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia

Microfluidic model of the platelet-generating organ: beyond bone marrow biomimetics

Disease surveillance based on Internet-based linear models: an Australian case study of previously unmodeled infection diseases

Evolutionary action score identifies a subset of TP53 mutated myelodysplastic syndrome with favorable prognosis

Combined laser capture microdissection and serial analysis of gene expression from human tissue samples

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