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Showing 1–5 of 5 results
Advanced filters: Author: Kimara L. Targoff Clear advanced filters

  • Craniofacial malformations have been linked to congenital heart defects, as in 22q11.2 deletion syndrome, but the mechanisms linking these lineages remain unknown. Here they show that zebrafish nxk2.7 is expressed in cardiopharyngeal progenitors and has roles in craniofacial development that cannot be compensated for by nkx2.5.

    • Caitlin Ford
    • Carmen de Sena-Tomás
    • Kimara L. Targoff
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Cardiac developmental genes have been associated with regenerative potential. Here the authors identify a Nkx2.5-dependent gene regulatory network operating through ect2, psmb3, and psmd7 to orchestrate cell cycle re-entry, proteolysis, and mitochondrial metabolism during myocardial repair.

    • Carmen de Sena-Tomás
    • Angelika G. Aleman
    • Kimara L. Targoff
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Non-destructive methods to image metabolism in situ in living tissues are limited. Here the authors combine deuterium oxide probing and stimulated Raman scattering microscopy to image lipid metabolic dynamics and protein synthesis in cells and in vivo in mice, C. elegans, and zebrafish.

    • Lingyan Shi
    • Chaogu Zheng
    • Wei Min
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Previous versions of photoactivatable Cre recombinase (PA-Cre) suffered from unintentional recombination in dark conditions. Here, the authors develop an improved version of PA-Cre, called PA-Cre 3.0, which shows reduced leakiness and improved efficiency upon activation, and make mouse lines that express PA-Cre 3.0 conditionally.

    • Kumi Morikawa
    • Kazuhiro Furuhashi
    • Masayuki Yazawa
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • SCAPE 2.0 is a versatile imaging platform that enables real-time three-dimensional microscopy of cellular function and dynamic motion in living organisms at over 100 volumes per second with minimal photodamage, and high-throughput structural imaging in fixed, cleared and expanded samples.

    • Venkatakaushik Voleti
    • Kripa B. Patel
    • Elizabeth M. C. Hillman
    Research
    Nature Methods
    Volume: 16, P: 1054-1062