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Showing 1–10 of 10 results
Advanced filters: Author: Kimberly F. Fennell Clear advanced filters

  • Variation in SARS-CoV-2 viruses results in newly emergent virus lineages. Here, the authors characterize the BNT162b2 mRNA vaccines, adapted to two SARS-CoV-2 lineages, JN.1 and KP.2, measure responses elicited by these vaccines against contemporary and older SARS-CoV-2 variants in naive and antigen experienced animal models and describe the biophysical and structural properties of the spike proteins expressed by these vaccines.

    • Wei Chen
    • Kristin R. Tompkins
    • Kayvon Modjarrad
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

    • A. Cole Burton
    • Christopher Beirne
    • Roland Kays
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 8, P: 924-935

  • GPAT1 is a mitochondrial outer membrane protein that catalyzes the first step of glycerolipid biosynthesis. Cryo-EM structures and functional studies of human GPAT1 uncover the molecular architecture and mechanism of this important acyltransferase.

    • Zachary Lee Johnson
    • Mark Ammirati
    • Huixian Wu
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 22-30

  • Small molecule antagonists of CCR6 are potential drugs for autoimmune disorders. Here the authors present inactive structures of CCR6 bound by different allosteric antagonists from two series simultaneously, offering multiple approaches to inhibit CCR6.

    • David Jonathan Wasilko
    • Brian S. Gerstenberger
    • Huixian Wu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Exome sequence analysis of more than 5,000 schizophrenia cases and controls identifies a polygenic burden primarily arising from rare, disruptive mutations distributed across many genes, among which are those encoding voltage-gated calcium ion channels and the signalling complex formed by the ARC protein of the postsynaptic density; as in autism, mutations were also found in homologues of known targets of the fragile X mental retardation protein.

    • Shaun M. Purcell
    • Jennifer L. Moran
    • Pamela Sklar
    Research
    Nature
    Volume: 506, P: 185-190

  • Single particle cryo-electron microscopy of membrane proteins is limited by their small size and difficulty to orient. Here the authors generate recombinant antibodies against the 12 kDa fusion partner BRIL domain from apocytochrome b562 to use them as plug and play fiducial marks for structure determination of BRIL fused membrane proteins.

    • Somnath Mukherjee
    • Satchal K. Erramilli
    • Anthony A. Kossiakoff
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • As the sample size in cancer genome studies increases, the list of genes identified as significantly mutated is likely to include more false positives; here, this problem is identified as stemming largely from mutation heterogeneity, and a new analytical methodology designed to overcome this problem is described.

    • Michael S. Lawrence
    • Petar Stojanov
    • Gad Getz
    Research
    Nature
    Volume: 499, P: 214-218