Haematopoietic stem and progenitor cells (HSPCs) are found in unique bone marrow microenvironments. Silberstein and colleagues use imaging cytometry to quantitatively determine HSPC distribution in femoral bones. They find that HSPCs are in endosteal zones, in close proximity to specialized microvessels, and that they appear in a hypoxic state whether or not they are close to the vasculature.
- César Nombela-Arrieta
- Gregory Pivarnik
- Leslie E. Silberstein
