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Publisher Correction: ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

Neeltje van Doremalen
Teresa Lambe
Vincent J. Munster
Amendments and Corrections19 Jan 2021
Nature

Volume: 590, P: E24
Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

Intranasal inoculation of BALB/c and C57BL/6J mice with the bovine H5N1 clade 2.3.4.4b virus results in rapid fatal disease characterized with high viral titers in lung and brain. Interestingly, only the C57BL/6J mice develop neurologic disease.

Thomas Tipih
Vignesh Mariappan
Kyle Rosenke
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice

Here the authors show that a replicating RNA vaccine encoding the hemagglutinin (HA) of contemporary H5N1 strains confers single shot protection against lethal H5N1 challenge in mice, while an RNA encoding the HA of a historical strain H5N1 confers only partial protection.

David W. Hawman
Thomas Tipih
Heinz Feldmann
ResearchOpen Access14 Jan 2025
Nature Communications

Volume: 16, P: 1-8
Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21

Non-neutralizing antibodies against the nucleoprotein (NP) of Crimean-Congo hemorrhagic fever virus are protective against lethal challenge in mice. Here, the authors show that these anti-NP antibodies protect through the intracellular antibody receptor TRIM21 and that protection is independent of T cells.

Shanna S. Leventhal
Thomas Bisom
David W. Hawman
ResearchOpen Access25 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model

While vaccines protecting against SARS-CoV-2 infection are approved, currently, there are no drugs suitable for high-risk exposure use against SARS-CoV-2. Here, Rosenke et al. provide evidence that orally delivered MK-4482, a nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model.

Kyle Rosenke
Frederick Hansen
Michael A. Jarvis
ResearchOpen Access16 Apr 2021
Nature Communications

Volume: 12, P: 1-8
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

The nucleotide analogue prodrug remdesivir reduces viral load and lung disease in a rhesus macaque model of SARS-CoV-2 infection.

Brandi N. Williamson
Friederike Feldmann
Emmie de Wit
Research09 Jun 2020
Nature

Volume: 585, P: 273-276
ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

The ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 induces an immune response in rhesus macaques and leads to reduced SARS-CoV-2 viral loads in respiratory tissues and an absence of pneumonia, but not to a reduction in nasal virus shedding, compared with unvaccinated animals.

Neeltje van Doremalen
Teresa Lambe
Vincent J. Munster
Research30 Jul 2020
Nature

Volume: 586, P: 578-582
A DNA-based vaccine protects against Crimean-Congo haemorrhagic fever virus disease in a Cynomolgus macaque model

A DNA-based vaccine elicits humoral and cellular immunity and provides protection against Crimean-Congo haemorrhagic fever virus-mediated disease in a non-human primate model.

David W. Hawman
Gustaf Ahlén
Ali Mirazimi
Research30 Nov 2020
Nature Microbiology

Volume: 6, P: 187-195
Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

The E3 ubiquitin ligase TRIM7 polyubiquitinates the envelope protein of Zika virus, adding Lys63-linked polyubiquitin chains that interact with the TIM1 receptor of host cells to enhance virus entry and replication.

Maria I. Giraldo
Hongjie Xia
Ricardo Rajsbaum
Research08 Jul 2020
Nature

Volume: 585, P: 414-419
Respiratory disease in rhesus macaques inoculated with SARS-CoV-2

Infection with SARS-CoV-2 in rhesus macaques causes a respiratory disease that recapitulates aspects of COVID-19 in humans, establishing this species as an animal model for investigating the pathogenesis of SARS-CoV-2.

Vincent J. Munster
Friederike Feldmann
Emmie de Wit
Research12 May 2020
Nature

Volume: 585, P: 268-272
A replicating RNA vaccine protects against severe fever with thrombocytopenia syndrome virus infection in mice

Allie Stamper
Thomas Bisom
David W. Hawman
ResearchOpen Access16 Oct 2025
npj Vaccines

Volume: 10, P: 1-9
Single dose VSV-based vaccine protects mice against lethal heterologous Crimean-Congo hemorrhagic fever virus challenge

Thomas Tipih
Shanna S. Leventhal
David W. Hawman
ResearchOpen Access30 May 2025
npj Vaccines

Volume: 10, P: 1-13
Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase

Kathleen F Benson
Feng-Qian Li
Marshall Horwitz
Research03 Aug 2003
Nature Genetics

Volume: 35, P: 90-96
Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection

Deepashri Rao
Matthew Lewis
David W. Hawman
ResearchOpen Access27 Feb 2025
npj Viruses

Volume: 3, P: 1-9
Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice

Shanna S. Leventhal
Carl Shaia
David W. Hawman
ResearchOpen Access19 Dec 2024
npj Vaccines

Volume: 9, P: 1-9
A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever

David W. Hawman
Shanna S. Leventhal
Heinz Feldmann
ResearchOpen Access20 May 2024
npj Vaccines

Volume: 9, P: 1-9
A live-attenuated viral vector vaccine protects mice against lethal challenge with Kyasanur Forest disease virus

Bharti Bhatia
Kimberly Meade-White
Heinz Feldmann
ResearchOpen Access14 Dec 2021
npj Vaccines

Volume: 6, P: 1-11
ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge

Robert J. Fischer
Jyothi N. Purushotham
Vincent J. Munster
ResearchOpen Access02 Mar 2021
npj Vaccines

Volume: 6, P: 1-11
A single dose of a vesicular stomatitis virus-based influenza vaccine confers rapid protection against H5 viruses from different clades

Wakako Furuyama
Pierce Reynolds
Andrea Marzi
ResearchOpen Access10 Jan 2020
npj Vaccines

Volume: 5, P: 1-10

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Publisher Correction: ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice

Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21

Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

A DNA-based vaccine protects against Crimean-Congo haemorrhagic fever virus disease in a Cynomolgus macaque model

Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

Respiratory disease in rhesus macaques inoculated with SARS-CoV-2

A replicating RNA vaccine protects against severe fever with thrombocytopenia syndrome virus infection in mice

Single dose VSV-based vaccine protects mice against lethal heterologous Crimean-Congo hemorrhagic fever virus challenge

Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase

Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection

Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice

A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever

A live-attenuated viral vector vaccine protects mice against lethal challenge with Kyasanur Forest disease virus

ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge

A single dose of a vesicular stomatitis virus-based influenza vaccine confers rapid protection against H5 viruses from different clades

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