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Showing 1–5 of 5 results
Advanced filters: Author: Kin Man Suen Clear advanced filters

  • The C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 form elongated condensates in vivo.

    • Kin Man Suen
    • Fabian Braukmann
    • Eric Alexander Miska
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The Shc adaptor proteins are normally recruited to activated receptor tyrosine kinases to mediate activation of downstream components of the signaling pathway. Shc is now shown to sequester ERK and prevent its spurious activation in the absence of stimuli, which could otherwise give rise to aberrant growth.

    • Kin Man Suen
    • Chi-Chuan Lin
    • John E Ladbury
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 620-627

  • Interactions between the peripheral juxtamembrane and C-terminal tail regions and the phosphorylation state of the kinase domain of the receptor tyrosine kinase FGFR2 fine tunes its signaling outputs.

    • Chi-Chuan Lin
    • Lukasz Wieteska
    • John E. Ladbury
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-14

  • Lin et al. investigate the interactions between adaptor protein, Grb2, and the ubiquitously expressed protein tyrosine phosphatase, Shp2. They find that monomeric Grb2 can activate Shp2 and its downstream signalling in the absence of up-regulation of receptor tyrosine kinases in response to different cellular conditions. They find that cancer-related signalling in breast cancer cells can be attributed to the binding of Grb2 to Shp2.

    • Chi-Chuan Lin
    • Lukasz Wieteska
    • John E. Ladbury
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11