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Showing 1–4 of 4 results
Advanced filters: Author: Kiyoharu J. Miyagishima Clear advanced filters

  • Miyagishima et al. investigate the pathological mechanisms underlying mutant CTRP5 function in late-onset retinal degeneration (L-ORD). With human iPSC-derived RPE cells, they demonstrate that in L-ORD iRPE, constitutive activation of AMPK disrupts cellular metabolism/energy homoeostasis, changes apical/basal VEGF secretion, and Metformin treatment corrects these associated phenotypes.

    • Kiyoharu J. Miyagishima
    • Ruchi Sharma
    • Kapil Bharti
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-16

  • How tissues adapt to extreme cold is not well understood. Here, the authors discover a mechanism that promotes FOXO1-mediated cold survival gene transcription at low temperatures, with potential implications for long-term tissue storage for transplantation.

    • Xiaomei Zhang
    • Lihao Ge
    • Jingxing Ou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Age-related macular degeneration is characterized by lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE). Here the authors report an in vitro iPSC-RPE model for AMD that recapitulates drusen and RPE atrophy, and identify two drugs that reduce drusen deposits and restore RPE epithelial phenotype.

    • Ruchi Sharma
    • Aman George
    • Kapil Bharti
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • This study characterizes the composition of the retinal ganglion cell (RGC) layer and the distribution of RGCs in the cone-dominant ground squirrel retina. The RGC density and the anatomical features of axon-astrocyte interaction in the ground squirrel resemble primates, rendering it an excellent alternative model for RGC neurodegeneration and neuroprotection.

    • Xuan Xiao
    • Tantai Zhao
    • Francisco M. Nadal-Nicolás
    Research
    Laboratory Investigation
    Volume: 101, P: 1289-1303