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The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model

Dysregulation of microRNAs has been implicated in neurodevelopmental disorders, including schizophrenia. Here the authors show that the TLX-miR-219 cascade regulates the proliferation of neural stem cells during normal development, and this pathway is dysregulated in a schizophrenia iPSC model.

Kiyohito Murai
Guoqiang Sun
Yanhong Shi
ResearchOpen Access11 Mar 2016
Nature Communications

Volume: 7, P: 1-15
miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells

The microRNA miR-137 is enriched in the brain of mice and induces the differentiation of adult neural stem cells. Now, Sun and colleagues report that miR-137 negatively regulates proliferation of neurons in embryonic mice and that TLX and LSD1 cooperate to negatively regulate miR-137 expression, blocking premature differentiation.

GuoQiang Sun
Peng Ye
Yanhong Shi
Research08 Nov 2011
Nature Communications

Volume: 2, P: 1-10
Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

TLX is a nuclear receptor essential for neural stem cell self-renewal and recently involved in glioblastoma development. In this study, the authors show that inhibition of TLX expression, achieved using a dendrimer nanovector-delivered siRNAs or viral vector-delivered shRNAs, reduces glioblastoma stem cells self renewal and in vivotumour growth through activation of TET3.

Qi Cui
Su Yang
Yanhong Shi
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-15
KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells.

Anqi Geng
Runxiang Qiu
Qiang Lu
ResearchOpen Access13 Jul 2018
Nature Communications

Volume: 9, P: 1-16
N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression

Gen Matsumoto
Tomonao Inobe
Nozomu Mori
ResearchOpen Access25 Jun 2018
Scientific Reports

Volume: 8, P: 1-14

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The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model

miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells

Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression

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