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Showing 1–5 of 5 results
Advanced filters: Author: Klaus Heger Clear advanced filters

  • NEDD4-binding protein 1 (N4BP1) is identified as a suppressor of cytokine production that is inactivated by caspase-8, which provides insight into the mechanisms underlying the immunodeficiency caused by mutations in FADD and caspase-8.

    • Alexander D. Gitlin
    • Klaus Heger
    • Vishva M. Dixit
    Research
    Nature
    Volume: 587, P: 275-280

  • RIPK1 plays a key role in several inflammatory and cell death signalling pathways. Understanding its regulation is pivotal for identifying diseases that might therapeutically benefit from RIPK1 inhibition. Recent studies now show that TBK1 and IKKε constitute a cell death checkpoint that restrains RIPK1 activation.

    • Klaus Heger
    • Vishva M. Dixit
    News & Views
    Nature Cell Biology
    Volume: 20, P: 1330-1331

  • OTULIN, which removes ubiquitin chains deposited by LUBAC, promotes LUBAC activity by preventing its auto-ubiquitination, thereby supporting normal mouse embryo development and preventing pro-inflammatory cell death in adult mice.

    • Klaus Heger
    • Katherine E. Wickliffe
    • Vishva M. Dixit
    Research
    Nature
    Volume: 559, P: 120-124

  • Immune cells are generally considered to be able to move through tissues using nonadhesive amoeboid migration mechanics. Here, the authors show that, unlike other immune cells, mast cells do not use this method and instead are completely reliant on integrin–ECM interactions.

    • Lukas Kaltenbach
    • Paloma Martzloff
    • Tim Lämmermann
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 915-924