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Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction

Class switch recombination (CSR) is a process contributing to antibody diversity and generating characteristic genomic junctions that reflect DNA double-strand break repair efficiency. Here authors present a platform to profile the repertoire of CSR junction patterns; long-read-sequenced PCR products from blood-derived lymphocytes are analysed by a dedicated bioinformatic pipeline to accurately detect immunodeficiencies and DNA repair defects.

Clara Vázquez García
Benedikt Obermayer
Kathrin de la Rosa
ResearchOpen Access19 Dec 2025
Nature Communications

Volume: 16, P: 1-15
Correction: Corrigendum: Cortical reorganization consistent with spike timing–but not correlation-dependent plasticity

Joshua M Young
Wioletta J Waleszczyk
Klaus Obermayer
Amendments and Corrections01 Aug 2007
Nature Neuroscience

Volume: 10, P: 1073
Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis

Schneeberger, Kim, Geesdorf, Rajewsky, Heppner et al. tease IL-12 and IL-23 signaling apart in mouse models and human brain tissue to define a role for oligodendroglial and neuronal IL-12 signaling in neuroimmune crosstalk in Alzheimer’s disease.

Shirin Schneeberger
Seung Joon Kim
Frank L. Heppner
ResearchOpen Access13 Mar 2025
Nature Aging

Volume: 5, P: 622-641
Invariant computations in local cortical networks with balanced excitation and inhibition

Jorge Mariño
James Schummers
Mriganka Sur
Research23 Jan 2005
Nature Neuroscience

Volume: 8, P: 194-201
Rapid internal contraction boosts DNA friction

Single-molecule force spectroscopy provides useful quantitative information about the properties of macromolecules. Otto and colleagues non-invasively inspect the tension dynamics in a taut strand of DNA, thereby extending the use of single-molecule force spectroscopy to the study of macromolecular dynamics.

Oliver Otto
Sebastian Sturm
Klaus Kroy
ResearchOpen Access30 Apr 2013
Nature Communications

Volume: 4, P: 1-7
Cortical reorganization consistent with spike timing–but not correlation-dependent plasticity

Joshua M Young
Wioletta J Waleszczyk
Klaus Obermayer
Research27 May 2007
Nature Neuroscience

Volume: 10, P: 887-895

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Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction

Correction: Corrigendum: Cortical reorganization consistent with spike timing–but not correlation-dependent plasticity

Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis

Invariant computations in local cortical networks with balanced excitation and inhibition

Rapid internal contraction boosts DNA friction

Cortical reorganization consistent with spike timing–but not correlation-dependent plasticity

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