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Showing 1–5 of 5 results
Advanced filters: Author: Kobe De Ridder Clear advanced filters

  • From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

    • Cristina Taddei
    • Bin Zhou
    • Majid Ezzati
    ResearchOpen Access
    Nature
    Volume: 582, P: 73-77

  • Determining the different cell types that contribute to a mixture of DNA is key for research and diagnostic applications. Here, authors comprehensively benchmark DNA methylation-based deconvolution methods, evaluating their performance and robustness to technical bias.

    • Kobe De Ridder
    • Huiwen Che
    • Bernard Thienpont
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • In cohorts of 498 pregnant women, methylation profiles from cell-free DNA, in addition to clinical risk factors, improved the early prediction of preeclampsia.

    • Marie De Borre
    • Huiwen Che
    • Bernard Thienpont
    Research
    Nature Medicine
    Volume: 29, P: 2206-2215

  • In this study, Vande Voorde et al. investigate the potential of untargeted metabolomics as a stratification tool for colorectal cancer (CRC). They present a comprehensive pipeline to uncover metabolic vulnerabilities in CRC based on its genetic origin. With this approach, they show perturbations in methionine metabolism linked to APC deficiency, and identify adenosylhomocysteinase as an actionable therapeutic target.

    • Johan Vande Voorde
    • Rory T. Steven
    • Owen J. Sansom
    ResearchOpen Access
    Nature Metabolism
    Volume: 5, P: 1303-1318