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Showing 1–5 of 5 results
Advanced filters: Author: Koen H. M. Prange Clear advanced filters

  • Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results in more stable atherosclerotic plaques.

    • Jeroen Baardman
    • Sanne G. S. Verberk
    • Jan Van den Bossche
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived CD40L reduces and stabilizes plaques through impaired Th1 polarization while platelet-derived CD40L ameliorates atherothrombosis.

    • Michael Lacy
    • Christina Bürger
    • Esther Lutgens
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Mokry et al. performed bulk RNA sequencing of 654 advanced human carotid plaques from the Athero-Express biobank and 162 coronary samples, and they show that unsupervised clustering defines plaque types corresponding to different cell compositions and clinical presentations. Circulating biomarkers can be potentially used to mark the different transcriptomic-defined plaque phenotypes.

    • Michal Mokry
    • Arjan Boltjes
    • Gerard Pasterkamp
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 1140-1155

  • Depuydt and Schaftenaar et al. profile the T cell clonality in patients with atherosclerosis by performing single-cell T cell receptor sequencing on carotid artery plaques and matched peripheral blood mononuclear cell samples. The analyses showed plaque-specific clonal expansion in effector CD4+ T cells, expressing genes indicative of exposure to activating antigens, thus suggesting that atherosclerosis has an autoimmune component driven by autoreactive CD4+ T cells.

    • Marie A. C. Depuydt
    • Frank H. Schaftenaar
    • Bram Slütter
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 112-125

  • This Review summarizes the role of transcription factors and epigenetic remodelling in modulating macrophage plasticity, provides an overview of the cooperative action of transcription factors and epigenetic modifiers controlling macrophage activation in the context of atherosclerosis and inflammation, and highlights the therapeutic potential of modulating transcription factor activity.

    • Tatyana Kuznetsova
    • Koen H. M. Prange
    • Menno P. J. de Winther
    Reviews
    Nature Reviews Cardiology
    Volume: 17, P: 216-228