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Showing 1–5 of 5 results
Advanced filters: Author: Konrad Knöpper Clear advanced filters

  • BATF3 is a member of the AP-1 transcription factor family. Kastenmüller and colleagues show that BATF3 is needed to promote memory CD8+ T cell responses. Activated CD8+ T cells transiently upregulate BATF3, which in turn suppresses expression of proapoptotic BIM to promote cell survival.

    • Marco A. Ataide
    • Karl Komander
    • Wolfgang Kastenmüller
    Research
    Nature Immunology
    Volume: 21, P: 1397-1407

  • CD62L+ precursors of exhausted T cells retain long-term proliferative potential, multipotency and repopulation capacity, and the transcription factor MYB is essential for the development and function of this population of cells.

    • Carlson Tsui
    • Lorenz Kretschmer
    • Axel Kallies
    ResearchOpen Access
    Nature
    Volume: 609, P: 354-360

  • This Review from Wolfgang Kastenmüller and colleagues highlights the heterogeneity that exists among lymph nodes at different anatomical locations. The authors consider the factors that contribute to lymph node heterogeneity and explain the relevance of this for the immune response, particularly in the contexts of vaccination and cancer.

    • Paulina Cruz de Casas
    • Konrad Knöpper
    • Wolfgang Kastenmüller
    Reviews
    Nature Reviews Immunology
    Volume: 24, P: 358-374