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Showing 1–5 of 5 results
Advanced filters: Author: Konstantin Gaengel Clear advanced filters

  • Secretory cells are major constituents of the lung airways, but their diversity, organization and specification are partially understood. Here, single-cell analysis reveals a differentiation gradient: proximal airway regions specialize in innate immunity, distal regions in lipid metabolism, while intermediate cells express low levels of both programs, driven by Fgfr2 signaling.

    • Alexandros Sountoulidis
    • Jonas Theelke
    • Christos Samakovlis
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-21

  • Endocytosis has proved to be a versatile mechanism regulating diverse cellular processes, ranging from nutrient uptake to intracellular signal transduction. New work reinforces the importance of endocytosis for VEGF receptor signalling and angiogenesis in the developing eye, and describes a mechanism for its differential regulation in angiogenic versus quiescent endothelial cells.

    • Konstantin Gaengel
    • Christer Betsholtz
    News & Views
    Nature Cell Biology
    Volume: 15, P: 233-235

  • Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous remodelling of cellular overlaps that maintain vessel integrity.

    • Hans Schoofs
    • Nina Daubel
    • Taija Mäkinen
    ResearchOpen Access
    Nature
    Volume: 641, P: 465-475

  • Fernández-Chacón et al. use imaging and scRNA-seq after targeting multiple Notch genes and angiogenic signaling pathways to find that the function of these pathways in vascular pathophysiology cannot be predicted by assessing transcriptional states.

    • Macarena Fernández-Chacón
    • Severin Mühleder
    • Rui Benedito
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 530-549

  • During development, groups of cells sometimes have to order themselves relative to a tissue in a coordinated manner, and this is true of ommatidial cells in the eye. Using a genetic and molecular approach, the Nemo kinase is shown to be involved in regulating the rate of ommatidial rotation; the study also links this event to cellular interaction through cadherin, important for coordinating reorientation.

    • Ivana Mirkovic
    • William J Gault
    • Marek Mlodzik
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 665-672