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Showing 1–9 of 9 results
Advanced filters: Author: Koshi Imami Clear advanced filters

  • Targeted protein degradation is a powerful tool, but difficult to achieve in vivo with high specificity and control. Here, the authors develop two in vivo targeted protein degradation systems in mice, which enable the selective degradation of target proteins in a cell type-specific manner and can be applied in both fetuses and neonates.

    • Motoi Yamashita
    • Chihiro Ogawa
    • Ichiro Taniuchi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Alveolar rhabdomyosarcoma is a clinically challenging disease due to the lack of druggable targets. Here the authors show preclinical evidence for ATR inhibitors as a therapeutic option for alveolar rhabdomyosarcoma.

    • Heathcliff Dorado García
    • Fabian Pusch
    • Anton G. Henssen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Here the authors characterise the impact of phosphorylation site mutations in intrinsically disordered regions (IDRs) on protein-protein interactions, highlighting the critical role of phosphorylation of IDRs in health and disease.

    • Trendelina Rrustemi
    • Katrina Meyer
    • Matthias Selbach
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Herpesviruses code for conserved protein kinases (CHPKs) that exert several regulatory functions by interacting with cellular factors. Here, the authors use affinity purification mass spectrometry (AP–MS) to identify differential interaction partners of CHPKs from seven different human herpesviruses, finding Cyclin A and associated factors as a specific signature of β-herpesvirus kinases.

    • Boris Bogdanow
    • Max Schmidt
    • Lüder Wiebusch
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The authors perform parallel transcriptome sequencing, tRNA qPCR array, ribosome profiling and mass spectrometry across five stages of mouse neocortex development to model the dynamic transcriptome-to-proteome transition, discovering a critical prenatal window during which translational control is predominant.

    • Dermot Harnett
    • Mateusz C. Ambrozkiewicz
    • Matthew L. Kraushar
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 1277-1290

  • The entire mRNA interactome capture has been established but identification of specific mRNA-binding proteins has been challenging. Here, the authors developed an in vivo RNA–protein crosslinking and RNA pulldown approach and characterized novel interactors of the C. elegans gld-1 mRNA, including DAZ-1 and miR-84.

    • Kathrin Theil
    • Koshi Imami
    • Nikolaus Rajewsky
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Subcellular localization of RNAs and proteins is important for polarized cells such as neurons. Here the authors differentiate mouse embryonic stem cells into neurons, and analyze the local transcriptome, proteome, and translated transcriptome in their cell bodies and neurites, providing a unique resource for future studies on neuronal polarity.

    • Alessandra Zappulo
    • David van den Bruck
    • Marina Chekulaeva
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13