The distortion of an amide group away from a planar conformation typically enhances its reactivity and such activation is usually achieved through the chemical synthesis of twisted amides. Now, it has been shown that a non-covalent activation strategy leading to accelerated hydrolysis can be achieved by binding a reactive twisted amide conformer inside a molecular cage.
- Hiroki Takezawa
- Kosuke Shitozawa
- Makoto Fujita
