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Showing 1–6 of 6 results
Advanced filters: Author: Kotaro Chihara Clear advanced filters

  • The Retron-Eco7 is a genetic element involved in anti-phage defense that encodes two effector proteins (PtuA and PtuB) and cleaves the host tRNA. Here, the authors solved the Retron-Eco7 complex structure using cryo-EM.

    • Junichiro Ishikawa
    • Kanta Yoneyama
    • Hiroshi Nishimasu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Retrons are bacterial genetic elements that, in combination with toxic effector proteins, can serve as antiphage defense systems. Here, the authors show that some phages can evade retrons and other defense systems by expressing specific tRNAs.

    • Aa Haeruman Azam
    • Kohei Kondo
    • Kotaro Kiga
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Two distinct phage engineering strategies—mutating phage genes targeted by bacterial anti-phage systems and arming phages with genes that counteract these systems—have enabled the circumvention of bacterial anti-phage defenses.

    • Wakana Yamashita
    • Kotaro Chihara
    • Kotaro Kiga
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-9

  • Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

    • Noah Sasa
    • Shohei Kojima
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 65-79

  • Biochemical, genetic and structural analyses show how phage ΦKZ co-opts the Pseudomonas aeruginosa gene expression machinery using a factor that binds to host ribosomes at 5S ribosomal RNA.

    • Milan Gerovac
    • Kotaro Chihara
    • Jörg Vogel
    ResearchOpen Access
    Nature Microbiology
    Volume: 9, P: 787-800