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Showing 1–3 of 3 results
Advanced filters: Author: Kotaro Soeda Clear advanced filters

  • Coordinated hormonal interactions in response to feeding and fasting regulate glucose homeostasis. Here the authors report that Activin B, expressed in the liver sinusoidal endothelial cells, is involved in glucose homeostasis by regulating hepatic FGF21 production and glucagon sensitivity and can be inhibited by adipocyte-derived FSTL3 during obesity.

    • Naoki Kobayashi
    • Yukiko Okazaki
    • Kohjiro Ueki
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Sasako et al. show that disruption of the insulin/IGF-1 signaling by suppressing Akt activity in mouse skeletal muscle can accelerate osteosarcopenia and shortens lifespan, which is reversed by inactivation of FoxOs rather than activation of mTOR, suggesting FoxOs as therapeutic targets.

    • Takayoshi Sasako
    • Toshihiro Umehara
    • Kohjiro Ueki
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18