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Showing 1–7 of 7 results
Advanced filters: Author: Krishna C. Suddala Clear advanced filters

  • T-box riboswitch RNAs directly bind to specific tRNA and regulate the transcription or translation of downstream genes in bacteria. Using single-molecule FRET and ensemble biophysical analyses, here the authors uncover a Venus flytrap-like mechanism where tRNA binding to a T-box riboswitch mRNA triggers its rapid domain closure.

    • Krishna C. Suddala
    • Janghyun Yoo
    • Jinwei Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Riboswitches bind intracellular metabolites and control bacterial gene expression. Here, by using X-ray crystallography, molecular dynamics simulations, and single-molecule fluorescence resonance energy transfer, the authors show how a local Mn2+ ion-binding signal is transduced across the yybP-ykoY riboswitch from Xanthomonas oryzae.

    • Krishna C. Suddala
    • Ian R. Price
    • Nils G. Walter
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

    • Fan Bu
    • Yagoub Adam
    • Zhichao Miao
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 399-411

  • By examining the structure of phospholipase C-β, an autoinhibitory helix that interacts with the catalytic core of this enzyme is now identified. Disrupting this interaction enhances basal activity and decreases stimulation by Gαq, supporting an allosteric mechanism for PLCβ activation through displacement of the autoinhibitory helix by Gαq.

    • Angeline M Lyon
    • Valerie M Tesmer
    • John J G Tesmer
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 999-1005

  • Riboswitches on 5′ ends of mRNAs are important for bacterial gene regulation. Here the authors probe the mechanism of a tRNA aminoacylation sensing T-box riboswitch using single-molecule fluorescence microscopy to characterize dynamic solution conformations and heterogeneous tRNA binding kinetics.

    • Krishna C. Suddala
    • Javier Cabello-Villegas
    • Nils G. Walter
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14