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Showing 1–5 of 5 results
Advanced filters: Author: Kristelle J. Capistrano Clear advanced filters

  • In a mouse model of breast cancer, a low-protein diet induces engulfment activities and mTORC1 signalling in tumour-associated macrophages to suppress engulfment-dependent mTORC1 signalling in MYC-overexpressing cancer cells through cell competition, serving as an innate immune defence mechanism to slow tumour growth.

    • Xian Zhang
    • Shun Li
    • Ming O. Li
    Research
    Nature
    Volume: 619, P: 616-623

  • A survey of T cell populations in human and mouse tumours identifies a population of cancer-sensing IL-15-activated αβ T cell receptor-positive FCER1G-expressing innate-like T cells with high cytotoxic potential.

    • Chun Chou
    • Xian Zhang
    • Ming O. Li
    Research
    Nature
    Volume: 605, P: 139-145

  • Depletion of transforming growth factor-β receptor 2 (TGFBR2) in CD4+ T cells results in IL-4-dependent vascular remodelling, stopping tumour growth in a transgenic mouse model of breast cancer, suggesting that type 2 immunity could be targeted for cancer treatments.

    • Ming Liu
    • Fengshen Kuo
    • Ming O. Li
    Research
    Nature
    Volume: 587, P: 115-120

  • 4T-Trap, a bispecific molecule designed to recognize CD4 and bind TGF-β, blocks TGF-β signalling in T helper cells, causing interleukin-4-dependent vascular reorganization and cancer cell death in a mouse model of breast cancer.

    • Shun Li
    • Ming Liu
    • Ming O. Li
    Research
    Nature
    Volume: 587, P: 121-125