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Group 3 innate lymphoid cell pyroptosis represents a host defence mechanism against Salmonella infection

Salmonella promotes IL-22 production in group 3 innate lymphoid cells (ILC3s) to promote infection, and invades ILC3s causing caspase-1 activation and pyroptosis, which control bacterial replication.

Lifeng Xiong
Shifeng Wang
Liang Zhou
Research06 Jun 2022
Nature Microbiology

Volume: 7, P: 1087-1099
Mitochondrial transcription factor A in RORγt⁺ lymphocytes regulate small intestine homeostasis and metabolism

RORγt is known to play critical roles in the regulation of a number of immune cell subsets. Here the authors implicate mitochondrial transcription factor A in the regulation of intestinal RORγt⁺ lymphocyte homeostasis and metabolic control in a murine in vivo model.

Zheng Fu
Joseph W. Dean
Liang Zhou
ResearchOpen Access22 Jul 2021
Nature Communications

Volume: 12, P: 1-16

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Group 3 innate lymphoid cell pyroptosis represents a host defence mechanism against Salmonella infection

Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism

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Mitochondrial transcription factor A in RORγt⁺ lymphocytes regulate small intestine homeostasis and metabolism