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Showing 1–19 of 19 results
Advanced filters: Author: Kristian Franze Clear advanced filters

  • Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-range chemical signalling.

    • Eva K. Pillai
    • Sudipta Mukherjee
    • Kristian Franze
    ResearchOpen Access
    Nature Materials
    P: 1-11

  • Spring-like force sensors bioprinted in the developing neural tube of growing chick embryos enable the measurement of forces generated by embryonic tissues with micrometre-level resolution.

    • Kristian Franze
    News & Views
    Nature Materials
    Volume: 23, P: 1471-1472

  • When exiting pluripotency but before irreversibly committing, embryonic stem cells pass through at least one transition state. It is now shown that in this metastable state the nuclei of the cells is auxetic, that is, when stretched their cross-section expands, and when compressed their cross-section contracts, and that this is in part a consequence from global chromatin de-condensation.

    • Stefano Pagliara
    • Kristian Franze
    • Kevin J. Chalut
    Research
    Nature Materials
    Volume: 13, P: 638-644

  • The mechanical microenvironment influences stem cell pluripotency. Here, the authors culture stem cells in microgels with controlled volumetric confinement and identify Plakoglobin as a mechanoresponsive regulator of pluripotency in mouse and human.

    • Timo N. Kohler
    • Joachim De Jonghe
    • Florian Hollfelder
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • The independent control of substrate stiffness and tethering of extracellular matrix to substrates for mechanical signalling investigations remains challenging. Here the authors present StemBond hydrogels, with stable ECM tethering that can be varied independently of stiffness, and use these to modulate the function of mouse and human pluripotent stem cells.

    • Céline Labouesse
    • Bao Xiu Tan
    • Kevin J. Chalut
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Atomic force microscopy indentation measurements of cells cultured on soft substrates may result in an underestimation of cell stiffness. A model has now been developed that takes this soft substrate effect into account, revealing that cortical cell stiffness is largely independent of substrate mechanics.

    • Johannes Rheinlaender
    • Andrea Dimitracopoulos
    • Kristian Franze
    Research
    Nature Materials
    Volume: 19, P: 1019-1025

  • Glial scars are thought to provide a biochemical and mechanical barrier to neuronal regeneration post-injury, but the mechanical properties of the scars have not been studied in detail. Here the authors perform atomic force microscopy measurements of glial scars from the injured rat cortex and spinal cord, and find that brain tissue softens in response to the injury.

    • Emad Moeendarbary
    • Isabell P. Weber
    • Kristian Franze
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • At high cell density or when plated on soft matrix, YAP/TAZ are redistributed from the nucleus to the cytosol, becoming transcriptionally inactive. Here the authors show that at high cell density, autophagosome formation is impaired due to reduced YAP/TAZ-dependent transcription of actomyosin genes

    • Mariana Pavel
    • Maurizio Renna
    • David C. Rubinsztein
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • Much of what is known about nervous system development is based on chemical signaling. In this study, Koser et al. demonstrate that developing neurons also respond to mechanical signals and that local tissue stiffness is a regulator of neuronal growth in vivo.

    • David E Koser
    • Amelia J Thompson
    • Kristian Franze
    Research
    Nature Neuroscience
    Volume: 19, P: 1592-1598

  • Many biomaterials have been developed which aim to match the elastic modulus of the brain for improved interfacing. However, other properties such as ultimate toughness, tensile strength, poroviscoelastic responses, energy dissipation, conductivity, and mass diffusivity also need to be considered.

    • Eneko Axpe
    • Gorka Orive
    • Eric A. Appel
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 11, P: 1-4