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Showing 1–6 of 6 results
Advanced filters: Author: Kristian Le Vay Clear advanced filters

  • Membrane-free complex coacervate microdroplets are compelling models for primitive compartmentalization, but it is unclear how molecular co-operativity influences physicochemical properties and activity of membrane-free compartments. Here, the authors use RNA/peptide coacervates as a model to reveal the relationship between coacervate properties and ribozyme activity.

    • Basusree Ghosh
    • Patrick M. McCall
    • T-Y. Dora Tang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Understanding the prebiotic origins of the nucleic acids is a long-standing challenge. The latest experiments support the idea that the first nucleic acid encoded information using a mixed ‘alphabet’ of RNA and DNA subunits.

    • Kristian Le Vay
    • Hannes Mutschler
    News & Views
    Nature
    Volume: 582, P: 33-34

  • Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via coacervation. Here authors demonstrate that a coacervate microenvironment supports RNA catalysis whilst selectively sequestering RNA based on length.

    • Björn Drobot
    • Juan M. Iglesias-Artola
    • T-Y Dora Tang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Non-equilibrium conditions at heated water-air interfaces can model Hadean microenvironments. Here, the authors show that such conditions enable one-pot synthesis, strand release and folding of functional RNAs similar to modern biological systems.

    • Annalena Salditt
    • Leonie Karr
    • Hannes Mutschler
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8

  • Catalytic mechanisms of enzymes are well understood, but achieving diverse reaction chemistries in re-engineered proteins can be difficult. Here the authors show a highly efficient and thermostable artificial enzyme that catalyzes a diverse array of substrate oxidations coupled to the reduction of H2O2.

    • Daniel W. Watkins
    • Jonathan M. X. Jenkins
    • J. L. Ross Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • High concentrations of prebiotic molecules and dry–wet cycles are difficult to achieve in a submerged system. Now, it has been shown that temperature gradients across gas bubbles in submerged rock pores can provide these conditions. Molecules are continuously accumulated at the warm side of bubbles at the gas–water interface, which enables or enhances many prebiotically relevant processes.

    • Matthias Morasch
    • Jonathan Liu
    • Dieter Braun
    Research
    Nature Chemistry
    Volume: 11, P: 779-788