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Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIV_AD8-EO infection

In this work, the authors study the immunological and virological effects of administering either wild-type anti-HIV-1 broadly neutralizing antibodies (bNAbs) or bNAbs with a mutation that increases binding to Fc-gamma receptors (FcγRs) to rhesus macaques in the acute phase of SHIV_AD8-EO infection.

Joana Dias
Giulia Fabozzi
Richard A. Koup
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

Vaccines against the WA1 SARS-CoV2 strain confer protection against other variants. However, the mechanisms underlying cross-protection are not fully understood. Here, the authors develop a method for rapid analysis of single B cells from patient samples and show that infection with a variant elicits convergent, public B cell responses to other variants.

Noemia S. Lima
Maryam Musayev
Daniel C. Douek
ResearchOpen Access14 Dec 2022
Nature Communications

Volume: 13, P: 1-14
Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates

Innate immune responses to mRNA vaccines are less well understood than adaptive immunity. Here, the authors comprehensively characterize the innate and adaptive immune responses to mRNA-1273 vaccinations in rhesus macaques and show how the vaccine activates interactions among components of the two systems.

Chaim A. Schramm
Damee Moon
Daniel C. Douek
ResearchOpen Access02 Dec 2023
Nature Communications

Volume: 14, P: 1-17
A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

An mRNA vaccine platform to prevent HIV-1 infection generated broadly neutralizing antibodies in non-human primates and protected some animals from infection, raising hope that optimization of this approach might lead to an effective HIV vaccine.

Peng Zhang
Elisabeth Narayanan
Paolo Lusso
Research09 Dec 2021
Nature Medicine

Volume: 27, P: 2234-2245
Lightning-induced reduction of phosphorus oxidation state

Phosphorus is frequently the limiting nutrient in marine and terrestrial ecosystems. Analysis of lightning-derived glassy compounds from North America, Africa and Australia suggests that cloud-to-ground lightning increases the bioavailability of this nutrient.

Matthew Pasek
Kristin Block
Research13 Jul 2009
Nature Geoscience

Volume: 2, P: 553-556
Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center

Leila Eslamizar
Constantinos Petrovas
Sampa Santra
ResearchOpen Access25 Jan 2021
npj Vaccines

Volume: 6, P: 1-10
Build your own soil: exploring microfluidics to create microbial habitat structures

Kristin Aleklett
E Toby Kiers
Edith C Hammer
ReviewsOpen Access14 Nov 2017
The ISME Journal

Volume: 12, P: 312-319

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Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIV_AD8-EO infection

Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates

A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

Lightning-induced reduction of phosphorus oxidation state

Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center

Build your own soil: exploring microfluidics to create microbial habitat structures

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Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection

Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates

A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

Lightning-induced reduction of phosphorus oxidation state

Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center

Build your own soil: exploring microfluidics to create microbial habitat structures

Search

Quick links

Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIV_AD8-EO infection