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Showing 1–4 of 4 results
Advanced filters: Author: Kristina Althoff Clear advanced filters

  • Alexander Schramm, Johannes Schulte and colleagues characterize 16 paired samples from patients with neuroblastoma at diagnosis and relapse using whole-exome sequencing, mRNA expression profiling, array CGH and DNA methylation analysis. Their data show the frequency, identity and evolution of genetic alterations in neuroblastoma.

    • Alexander Schramm
    • Johannes Köster
    • Johannes H Schulte
    Research
    Nature Genetics
    Volume: 47, P: 872-877

  • Elucidating specific effects of protein kinase Akt isoforms remains challenging. Here, the authors establish an Akt isoform-dependent cellular model system and use it, together with X-ray crystallography and structure-based ligand design, to develop isoform-selective covalent-allosteric Akt inhibitors

    • Lena Quambusch
    • Laura Depta
    • Daniel Rauh
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation of MHC class I via autophagy.

    • Phyllis F. Cheung
    • JiaJin Yang
    • Jens T. Siveke
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18