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Showing 1–4 of 4 results
Advanced filters: Author: Kristofferson Tandoc Clear advanced filters

  • Translational reprogramming during asparagine restriction, via activated MAPK signalling and enhanced translation of activating transcription factor 4 (ATF4) mRNA in melanoma and pancreatic cancer cells, provide a survival advantage.

    • Gaurav Pathria
    • Joo Sang Lee
    • Ze’ev A. Ronai
    Research
    Nature Cell Biology
    Volume: 21, P: 1590-1603

  • Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance.

    • Michael Jewer
    • Laura Lee
    • Lynne-Marie Postovit
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show that the tyrosine kinase c-Src stimulates mitochondrial function to signal energy sufficiency to mTORC1, increasing translation of the PRC2 subunits EZH2 and SUZ12 to support ErbB2-dependent tumours.

    • Harvey W. Smith
    • Alison Hirukawa
    • William J. Muller
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19